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11.
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12.
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Reconditioning of the Leuven Isotope Separator as a test bench for radioactive ion beam development
/ Wojtaczka, Wiktoria (Leuven U.) ; Caerts, Bart (Leuven U.) ; Heines, Michael (Leuven U.) ; Johnson, Jake D (Leuven U.) ; Rothe, Sebastian (CERN) ; Cocolios, Thomas E (Leuven U.)
Producing novel medical radionuclides in the quantities necessary for pre-clinical and clinical use requires an ion source able to handle high ion throughputs, operated efficiently, to deliver high specific activity samples. This is only possible with the understanding of how different parameters affect the ion source performance. [...]
2023 - 3 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 541 (2023) 399-401
In : 19th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS 2022), Daejeon, Korea, 3 - 7 Oct 2022
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13.
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Voltage scanning and technical upgrades at the Collinear Resonance Ionization Spectroscopy experiment
/ Athanasakis-Kaklamanakis, Michail (CERN ; Leuven U.) ; Reilly, Jordan R. (Manchester U.) ; Koszorús, Ágota (CERN) ; Wilkins, Shane G. (MIT) ; Lalanne, Louis (Leuven U.) ; Geldhof, Sarina (Leuven U.) ; Nichols, Miranda (Goteborg, ITP) ; Wang, Quanjun (Lanzhou U. (main)) ; van den Borne, Bram (Leuven U.) ; Chorlton, David (Manchester U.) et al.
To optimize the performance of the Collinear Resonance Ionization Spectroscopy (CRIS) experiment at CERN-ISOLDE, technical upgrades are continuously introduced, aiming to enhance its sensitivity, precision, stability, and efficiency. Recently, a voltage-scanning setup was developed and commissioned at CRIS, which improved the scanning speed by a factor of three as compared to the current laser-frequency scanning approach. [...]
arXiv:2303.15312.-
2023-05-17 - 10 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 541 (2023) 86-89
Fulltext: 2303.15312 - PDF; Publication - PDF;
In : 19th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS 2022), Daejeon, Korea, 3 - 7 Oct 2022, pp.86-89
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14.
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DFT calculations of Ti-based molecules clustering with Ar for laser-based enrichment of stable isotopes
/ Bernerd, Cyril (Leuven U. ; CERN) ; Cocolios, Thomas Elias (Leuven U.) ; Dooms, Lucas (Leuven U.) ; Ferrari, Piero (Leuven U. ; Nijmegen U.) ; Payne, Oliver (Leuven U.)
Within PRISMAP, the European medical radionuclides program, we are investigating the possible enrichment of titanium and calcium stable isotopes by means of Separation of Isotopes by Laser Assisted Retardation of Condensation (SILARC). Titanium or calcium-containing molecules are injected in a gas cell containing argon as a buffer gas and released via a nozzle creating a supersonic jet. [...]
2023 - 3 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 541 (2023) 141-143
In : 19th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS 2022), Daejeon, Korea, 3 - 7 Oct 2022, pp.141-143
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15.
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First on-line application of the high-resolution spectroscopy laser ion source PI-LIST at ISOLDE
/ Heinke, Reinhard (CERN) ; Au, Mia (CERN ; Mainz U.) ; Bernerd, Cyril (CERN ; Leuven U.) ; Chrysalidis, Katerina (CERN) ; Cocolios, Thomas E (Leuven U.) ; Fedosseev, Valentin N (CERN) ; Hendriks, Isabel (CERN ; Lund U. (main)) ; Jaradat, Asar A H (CERN) ; Kaja, Magdalena (Mainz U., Inst. Phys.) ; Kieck, Tom (Darmstadt, GSI ; Helmholtz Inst., Mainz) et al.
We report on the development, characterization, and first application of a specialized resonance ionization laser ion source for high-resolution spectroscopy applications below usual hot cavity Doppler broadening limitations, for on-line experiments at CERN-ISOLDE. The new PI-LIST ion source comprises perpendicular laser/atom beam interaction in a radio-frequency quadrupole unit directly downstream the hot atomizer cavity. [...]
2023 - 5 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 541 (2023) 8-12
Fulltext: PDF;
In : 19th International Conference on Electromagnetic Isotope Separators and Related Topics (EMIS 2022), Daejeon, Korea, 3 - 7 Oct 2022, pp.8-12
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16.
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Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [$^{153}$Sm]Sm-DOTA-TATE
/ Vermeulen, Koen (SCK-CEN, Mol) ; Van de Voorde, Michiel (SCK-CEN, Mol) ; Segers, Charlotte (SCK-CEN, Mol) ; Coolkens, Amelie (SCK-CEN, Mol) ; Pérez, Sunay Rodriguez (SCK-CEN, Mol) ; Daems, Noami (SCK-CEN, Mol) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Crabbé, Melissa (SCK-CEN, Mol) ; Opsomer, Tomas (SCK-CEN, Mol) ; Vargas, Clarita Saldarriaga (SCK-CEN, Mol) et al.
Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of $^{152}$Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-Am $^{153}$Sm. [...]
2022 - 15 p.
- Published in : Pharmaceutics 14 (2022) 2566
Fulltext: PDF;
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17.
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Resonant laser ionization and mass separation of $^{225}$Ac
/ Johnson, Jake D (Leuven U.) ; Heines, Michael (Leuven U.) ; Bruchertseifer, Frank (Geel, JRC) ; Chevallay, Eric (CERN) ; Cocolios, Thomas E (Leuven U.) ; Dockx, Kristof (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heinitz, Stephan (SCK-CEN, Mol) ; Heinke, Reinhard (Leuven U. ; CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) et al.
$^{225}$Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $^{225}$Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $^{225}$Ac itself. [...]
2023 - 11 p.
- Published in : Sci. Rep. 13 (2023) 1347
Fulltext: PDF;
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18.
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Observation of the radiative decay of the ${}^{229}\mathrm{Th}$ nuclear clock isomer
/ Kraemer, Sandro (Leuven U. ; LMU Munich (main)) ; Moens, Janni (Leuven U.) ; Athanasakis-Kaklamanakis, Michail (Leuven U. ; CERN) ; Bara, Silvia (Leuven U.) ; Beeks, Kjeld (Vienna, Tech. U., Atominst.) ; Chhetri, Premaditya (Leuven U.) ; Chrysalidis, Katerina (CERN) ; Claessens, Arno (Leuven U.) ; Cocolios, Thomas E. (Leuven U.) ; Correia, João G.M. (Lisbon U.) et al.
The nucleus of the radioisotope thorium-229 (${}^{229}$Th) features an isomer with an exceptionally low excitation energy that enables direct laser manipulation of nuclear states. For this reason, it is a leading candidate for use in next-generation optical clocks. [...]
arXiv:2209.10276.-
2023-05-24 - 15 p.
- Published in : Nature 617 (2023) 706–710
Fulltext: PDF;
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19.
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Study of the radiative decay of the low-energy isomer in $^{229}$Th
/ Chhetri, Premaditya (KU Leuven) ; Bara, Silvia (KU Leuven) ; Beeks, Kjeld (TU Wein) ; Bernerd, Cyril (KU Leuven, CERN) ; Block, Michael (GSI Darmstadt, HIM Mainz, University of Mainz) ; Claessens, Arno (KU Leuven) ; Cocolios, Thomas Elias (KU Leuven) ; Martins Correia, João Guilherme (Universidade de Lisboa) ; Granadeiro Costa, Angelo Rafael (KU Leuven) ; Cottenier, Stefaan (Ghent University) et al.
CERN-INTC-2022-017 ; INTC-P-628.
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2022.
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20.
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Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS
/ Heinke, Reinhard (CERN ; Leuven U.) ; Chevallay, Eric (CERN) ; Chrysalidis, Katerina (CERN) ; Cocolios, Thomas E (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Fedosseev, Valentin N (CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) ; Lambert, Laura (CERN) ; Leenders, Benji (Leuven U. ; SCK-CEN, Mol ; Gent U.) ; Marsh, Bruce A (CERN) et al.
Thulium-167 is a promising radionuclide for nuclear medicine applications with potential use for both diagnosis and therapy (“theragnostics”) in disseminated tumor cells and small metastases, due to suitable gamma-line as well as conversion/Auger electron energies. However, adequate delivery methods are yet to be developed and accompanying radiobiological effects to be investigated, demanding the availability of $^{167}$Tm in appropriate activities and quality. [...]
2021
- Published in : Frontiers in Medicine 8 (2021) 712374
Fulltext: PDF;
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