Capacidad de dosificación de vehículos semisólidos en cápsulas duras conteniendo piroxicam 20 mg

• NURIA SALAZAR ^[1] ; CARMEN TRIVES ^[1] ; y LUIS ALBERTO DEL RÍO ^[1]
  1. [1] Universidad CEU San Pablo

     Universidad CEU San Pablo

     Madrid, España

     
• Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4 4, 2005, págs. 849-859
• Idioma: español
• Títulos paralelos:
  • Dosage ability for liquid vehicles filling into hard gelatine capsules containing piroxicam 20 mg
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• Resumen

  • The aim of the article is to familiarize the pharmaceutical compounding phamacist with liquid and semisolids contents in the form of capsules. This type of formulations require simple tools. For that, Piroxicam has been chosen as a prototype active ingredient also they have been choosen vehicles with different physico-chemical properties, such as hydrophilic and lipophilic liquids that had to be thicker and another semisolid previously melt. They had been developed methods for the determination of the solubility, viscosity and dosage ability of the formulations. In addition the stability to diverse conditions has been evaluated. The best results have been found with Gelucire® 44/14, semisolid excipient with emulsifying characteristics. It is possible to find better profiles for the other tried formulations alive when the phenomenon of precipitation and retardation could be avoid in the stomach. Additionally, simplicity in their formulation, suitable manufacture and stability turn to this alternative interesting for it application in the oficinal Pharmacy.