Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile

• Autores: L. Mauriège, Denis R. Joanisse, S. Caspar-Bauguil, I. Lemieux, J. Bergeron, S Biron
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 71, Nº. 4, 2015, págs. 719-732
• Idioma: inglés
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• Resumen

  • Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS; n?=?25) or without (NDYS; n?=?23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (p?