Pathological N1/N2 in Clinical Stage I Bronchogenic Carcinoma. Analysis From a Prospective Multicentre Database
-
Alejandra Romero Román [1] ; Silvana Crowley Carrasco [1] ; Mariana Gil Barturen [1] ; Ana Royuela [4] ; Carme Obiols [2] ; Sergi Call [2] ; José Luis Recuero [3] ; Íñigo Royo [3] ; Raúl Embún [3] ; David Gómez de Antonio [1]
-
[1] Hospital Universitario Puerta de Hierro
Hospital Universitario Puerta de Hierro
Madrid, España
-
[2] Universitat de Barcelona
Universitat de Barcelona
Barcelona, España
-
[3] Hospital Clínico Universitario Lozano Blesa
Hospital Clínico Universitario Lozano Blesa
Zaragoza, España
-
[4] Unidad de Bioestadística, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), CIBERESP, Madrid, España
-
- Localización: Archivos de bronconeumología: Organo oficial de la Sociedad Española de Neumología y Cirugía Torácica SEPAR y la Asociación Latinoamericana de Tórax ( ALAT ), ISSN 0300-2896, Vol. 59, Nº. 6 (June), 2023, págs. 364-369
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
-
Resumen
Objectives To determine the incidence of occult N1/N2 nodal metastases and associated risk factors in patients with non-small cell lung cancer no larger than 3cm and deemed cN0 by CT and PET-CT in a prospective, multicentre national database.
Methods Patients with a NSCLC no larger than 3cm, deemed cN0 by PET-CT and CT scan, who had undergone at least a lobectomy, were selected from a national multicentre database of 3533 patients who had undergone anatomic lung resection between 2016 and 2018.
Clinical and pathological variables of patients with pN0 and patients with pN1/N2 were compared to identify factors associated with the presence of lymph node metastases. Chi2 and the Mann–Whitney U test were used for categorical and numerical variables, respectively. All variables with p<0.2 in the univariate analysis were included in the multivariate logistic regression analysis.
Results The study included 1205 patients from the cohort. The incidence of occult pN1/N2 disease was 10.70% (95%CI, 9.01–12.58).
The multivariable analysis revealed that the degree of differentiation, size, location (central or peripheral) and SUV of the tumour in PET, surgeon experience and number of lymph nodes resected were associated with occult N1/N2 metastases.
Conclusions The incidence of occult N1/N2 in patients with bronchogenic carcinoma with cN0 tumours no larger than 3cm is no negligible. Data about the degree of differentiation, tumour size in CT scan, maximal uptake of the tumour in PET-CT, location (central or peripheral), number of lymph nodes resected and surgeon seniority is relevant in order to detect patients at risk.