Fernando García Torres, Giovanni Santacroce, Irene Zammarchi, Pablo Meseguer Gancedo, María Rocío del Amor del Amor
In the management of UC, a chronic inflammatory bowel disease, histological evaluation plays an essential role in tar- geting histological remission (HR) of intestinal inflammatory activity as the primary aim of treatment. Recent work in the field has proposed a novel index called PHRI that quantifies UC activity based on the presence or absence of neutrophils in different cellular compartments: lamina propria, cryptal epithelium, surface epithelium and cryptal lumen. Digiti- zation of tissue samples into whole-slide images (WSI) has permitted the implementation of computer vision algorithms. These can perform tasks such as semantic segmentation but they require detailed pixel-level annotations, which are labo- rious and time-consuming in gigapixel images such as WSI. To address this limitation, this work introduces an active learning (AL) algorithm, an innovative approach to alleviat- ing the workload of pathologists by improving the efficiency in identifying crucial ...
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