Synchronous cemento-ossifying fibromas: a systematic review

• Bruna Luísa Neumann ^[1] ; Eduarda Martins Mendes ^[1] ; Bruna Barcelos Só ^[1] ; Felipe Martins Silveira ^[2] ; Vivian Petersen Wagner ^[3] ; Pablo Agustin Vargas ^[8] ; Jean Nunes Dos Santos ^[4] ; Felipe Paiva Fonseca ^[5] ; Ronell Eduardo Bologna-Molina ^[2] ; Adalberto Mosqueda-Taylor ^[6] ; Marco Antonio Trevizani Martins ^[7] ; Manoela Domingues Martins ^[1] ; Lauren Frenzel Schuch ^[2]
  1. [1] Universidade Federal do Rio Grande do Sul

     Universidade Federal do Rio Grande do Sul

     Brasil

     
  2. [2] Universidad de la República

     Universidad de la República

     Uruguay

     
  3. [3] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  4. [4] Universidade Federal da Bahia

     Universidade Federal da Bahia

     Brasil

     
  5. [5] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  6. [6] Universidad Autónoma Metropolitana

     Universidad Autónoma Metropolitana

     México

     
  7. [7] Hospital de Clínicas de Porto Alegre

     Hospital de Clínicas de Porto Alegre

     Brasil

     
  8. [8] Department of Oral Diagnosis, Piracicaba Dental School, Campinas University, Piracicaba, SP, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 5 (September), 2024
• Idioma: inglés
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• Resumen

  • This systematic review aimed to incorporate published data regarding synchronous cemento-ossifying fibromas (COF), with an analysis of their demographic and clinicopathological characteristics.

    Case reports and case series of synchronous COF were searched in PubMed, Web of Science, Scopus, EMBASE, and LILACS according to the PRISMA (2020) statement. Also, a manual search was carried out and the grey literature was assessed. A descriptive statistical analysis was performed.

    Nineteen studies comprising 20 cases of synchronous COF were included. The mean age at diagnosis was 35 years (±13.8), with a predominance of female patients (n=12/60%). In 13 cases (65%) the mandible and the maxilla were affected simultaneously. In two cases (10%) first-degree relatives (parents or siblings) had been previously diagnosed with COF. The diagnostic hypotheses were reported in 8 cases (40%), with florid cemento-osseous dysplasia, ameloblastic fibroodontoma, calcifying cystic odontogenic tumor, osteoma and cementoblastoma being cited in the differential diagnosis. Among the cases with details about management (n=17), eleven were treated by surgical enucleation and/or excision (64.7%). Follow-up was provided for 10 cases (50%), with a mean period of 44.7±62.19 months. Recurrence occurred in three of informed cases.

    Synchronous manifestation of COF is rare. Female patients around the 3rd decade of life are more commonly affected. Bilateral involvement of the mandible and maxilla is the most common clinical presentation.