Head and neck myofibroma: a case series of 16 cases and literature review

• Lucas Lacerda de Souza ^[4] ; Felipe Paiva Fonseca ^[5] ; Cinthia Veronica Bardález López de Cáceres ^[1] ; Ciro Dantas Soares ^[6] ; Alberto da Costa Gurgel ^[7] ; Hélder Antônio Rebelo Pontes ^[2] ; Flávia Sirotheau Corrêa Pontes ^[2] ; Carolina Almeida Paradela ^[2] ; Ivan José Correia-Neto ^[4] ; Yuri Kalinin ^[8] ; Marcio Ajudarte Lopes ^[4] ; Alan Roger Santos-Silva ^[4] ; Oslei Paes de Almeida ^[4] ; Pablo Agustin Vargas ^[9] ; Liam Robinson ^[3] ; Willie F P van-Heerden ^[3]
  1. [1] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  2. [2] Universidad Federal de Pará

     Universidad Federal de Pará

     Brasil

     
  3. [3] University of Pretoria

     University of Pretoria

     City of Tshwane, Sudáfrica

     
  4. [4] Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
  5. [5] Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Department of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
  6. [6] Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Department of Pathology, Getulio Sales Diagnósticos, Natal, Rio Grande do Norte, Brazil
  7. [7] Department of Pathology, Getulio Sales Diagnósticos, Natal, Rio Grande do Norte, Brazil
  8. [8] City Hall of the Seaside Resort of Praia Grande, São Paulo, Brazil
  9. [9] Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Department of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 6 (Noviembre), 2024
• Idioma: inglés
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• Resumen

  • This study aimed to explore the clinical, histopathologic, and immunohistochemical characteristics of myofibromas (MFs) affecting the head and neck region.

    Formalin-fixed paraffin-embedded tissue blocks of patients diagnosed with MFs in the head and neck were retrieved from the archives of three oral and maxillofacial pathology laboratories. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed, and follow-up status were retrieved from the patient's medical records or pathology reports.

    Sixteen cases were included in the study. Females were slightly more affected than males. The first and second decades of life were more prevalent. The most common locations were the alveolar ridge and cheek. Although rare, some of the patients were presented with intraosseous lesions. Microscopically, tumors consisted of plump, spindle-shaped myofibroblasts arranged in whorls or fascicles with varying degrees of differentiation. Immunohistochemically, diffuse positivity for vimentin and α-SMA was observed, while Ki-67 mostly showed low immunoreactivity (<5%). Treatment primarily involved complete excision.

    MFs in the head and neck region are rare and predominantly affect female patients during the second decade of life. Despite their rarity, central MFs should be considered in the differential diagnosis of intraosseous lesions in infants.