Goodness-of-fit and local identifiability of a receptor-binding radio-pharmacokinetic system | IEEE Journals & Magazine | IEEE Xplore

Goodness-of-fit and local identifiability of a receptor-binding radio-pharmacokinetic system


Abstract:

A four-state nonlinear model describing a radiopharmacokinetic system for a hepatic receptor-binding radiopharmaceutical, (/sup 99m/Tc)-galactosyl-neoglycoalbumin, (TcNGA...Show More

Abstract:

A four-state nonlinear model describing a radiopharmacokinetic system for a hepatic receptor-binding radiopharmaceutical, (/sup 99m/Tc)-galactosyl-neoglycoalbumin, (TcNGA), was tested for goodness-of-fit and local identifiability using scanning data from nine healthy subjects and seven patients with severe liver disease. Based on standard deviations of liver and heart imaging data at equilibria as a measure of observational error, the reduced chi-square ranged from 0.5 to 2.6. Values above 1.2 occurred when the subject moved during the 30 min study. Relative standard errors for each parameter were determined. The highest standard errors occurred when the amount of TcNGA injected exceeded the total amount of receptor. Therefore, when TcNGA functional imaging was performed without excess patient motion and receptor saturation, the kinetic model provided data fits of low systematic error and yielded high precision estimates of receptor concentration and forward binding rate constant.<>
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 39, Issue: 4, April 1992)
Page(s): 356 - 367
Date of Publication: 30 April 1992

ISSN Information:

PubMed ID: 1592401

References

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