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Optimization of symptomatic therapy in Parkinson's disease | IEEE Journals & Magazine | IEEE Xplore

Optimization of symptomatic therapy in Parkinson's disease


Abstract:

A third-order nonlinear mathematical model of the dose-effect relationship of levodopa, one of the most common drugs used for the symptomatic therapy of Parkinson's disea...Show More

Abstract:

A third-order nonlinear mathematical model of the dose-effect relationship of levodopa, one of the most common drugs used for the symptomatic therapy of Parkinson's disease, is derived with the aid of a visual-tracking-based method which allows the measurement of some Parkinsonian symptoms quantitatively and objectively. The parameters of this model are identified for each subject separately due to the large interpatient variability in response to treatment. The model is then used to optimize the dosage regimen for each patient individually (according to the clinical particularities and needs of each patient) with respect to an objective function which includes the symptoms dynamically and the total amount of levodopa which is to be administered. Encouraging clinical results of this control engineering approach to therapy optimization are presented. The advantages and drawbacks of this approach are discussed and further research directions are indicated.<>
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 36, Issue: 3, March 1989)
Page(s): 363 - 372
Date of Publication: 31 March 1989

ISSN Information:

PubMed ID: 2921071

References

References is not available for this document.