ER has seen the deaths and abrupt exits of several beloved characters over the course of its fifteen-year run, most notably Dr. Mark Greene in Season 8–but why was he killed off? ER, created by physician and sci-fi novelist Michael Crichton (creator of Jurassic Park and Westworld), premiered on NBC in 1994 and went on to become the second-longest-running medical drama behind Grey’s Anatomy, with a total of 331 episodes over 15 seasons before terminating in 2009.
Dr. Greene was one of ER’s most inherently likable leading men, as well as, perhaps, the overall major protagonist through ER season 8. He was played by Anthony Edwards, the Emmy and Golden Globe-winning star of Top Gun and Revenge of the Nerds fame. Dr. Greene remained a close friend and an authority figure to his fellow medical team from the debut episode of ER, which began with him tending to his intoxicated friend Dr. Doug Ross (George Clooney) while still monitoring a dozen gravely injured patients, to his final moments in ER season 8. With his terrible death from a brain tumor in ER season 8, the cast and fans of the primetime television series were left with a gap.