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== Function ==
== Function ==


KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth<ref>{{cite journal|pmid=14618103}}</ref>. KIF15 maintains bipolar microtubule [[spindle apparatus]] in dividing cells and shares redundant functions with [[KIF11]] <ref>{{cite journal|pmid=19818618;}}</ref><ref>{{cite journal|pmid=19818619}}</ref> . KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between [[centrosomes]]. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner <ref>{{cite journal|pmid=22024925}}</ref><ref>{{cite journal|pmid=22214669}}</ref>.
KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth<ref>{{cite journal|pmid=14618103}}</ref>. KIF15 maintains bipolar microtubule [[spindle apparatus]] in dividing cells and shares redundant functions with [[KIF11]] <ref>{{cite journal|pmid=19818619}}</ref> . KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between [[centrosomes]]. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner <ref>{{cite journal|pmid=22024925}}</ref><ref>{{cite journal|pmid=22214669}}</ref>.


== Function in neurons ==
== Function in neurons ==

Revision as of 22:22, 30 December 2012

Template:PBB Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.[1]

This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons.[1]

Function

KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth[2]. KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11 [3] . KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner [4][5].

Function in neurons

KIF15 restricts the movement of short microtubules into growing axons by generating forces on microtubules which counteract those generated by cytoplasmic dynein [6] [7]. KIF15, together with KIF23 become enriched in dendrites as neurons mature to promote the transport of minus-end distal microtubules into nascent dendrites [8]

Interactions

KIF15 has been shown to interact with TPX2. Both these dimers cooperate to slide along microtubules and maintain bipolar spindles [9] [10]

References

  1. ^ a b "Entrez Gene: Kinesin family member 15".
  2. ^ . PMID 14618103. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. ^ . PMID 19818619. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. ^ . PMID 22024925. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. ^ . PMID 22214669. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  6. ^ . PMID 23035110. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  7. ^ . PMID 21048148. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  8. ^ . PMID 23035110. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  9. ^ . PMID 19818618. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  10. ^ . PMID 21936781. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

Further reading

  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 23035110, please use {{cite journal}} with |pmid=23035110 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22851319, please use {{cite journal}} with |pmid=22851319 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22709276, please use {{cite journal}} with |pmid=22709276 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22214669, please use {{cite journal}} with |pmid=22214669 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22140519, please use {{cite journal}} with |pmid=22140519 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21936781, please use {{cite journal}} with |pmid=21936781 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21873565, please use {{cite journal}} with |pmid=21873565 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21048148, please use {{cite journal}} with |pmid=21048148 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19818618, please use {{cite journal}} with |pmid=19818618 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19005009, please use {{cite journal}} with |pmid=19005009 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17720869, please use {{cite journal}} with |pmid=17720869 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16682350, please use {{cite journal}} with |pmid=16682350 instead.
  • Mayer, Thomas. [[1] "Thomas Mayer Lab"]. Research. {{cite web}}: Check |url= value (help); ref stripmarker in |url= at position 1 (help)
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  1. ^ {{cite web|last=Mayer|first=Thomas|url=http://www.uni-konstanz.de/thomasmayer/research.html%7Cwork=Research}}
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