PSB-CB5

PSB-CB5
Identifiers
	IUPAC name (2Z)-2-[(3-[(4-chlorophenyl)methoxy]phenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one;
CAS Number	1627710-30-8 ;
PubChem CID	85469571;
ChemSpider	34226942;
UNII	75Q5Q6F7LA;
CompTox Dashboard (EPA)	DTXSID301031964 ;
Chemical and physical data
Formula	C20H17ClN2O2S
Molar mass	384.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4ccc(cc4)COc(c2)cccc2\C=C(\C1=O)/N=C3N1CCCS3;
	InChI InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-; Key:XJBQRMOGMULGPP-PDGQHHTCSA-N;

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PSB-CB5 (CID-85469571) is a compound which acts as an antagonist at the former orphan receptor GPR18, and is the first selective antagonist characterised for this receptor, with an IC₅₀ of 279nM, and good selectivity over related receptors (over 36x selectivity vs CB₁ and GPR55, and 14x vs CB₂.) As all previously known antagonists for GPR18 also antagonise GPR55, it has been difficult to separate the effects of these two receptor targets, so the discovery of a selective GPR18 antagonist is expected to be useful in research into the actions of this receptor.^[1]^[2]^[3]

References

^ Rempel V, Atzler K, Behrenswerth A, Karcz T, Schoeder C, Hinz S, et al. (2014). "Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55". MedChemComm. 5 (5): 632–49. doi:10.1039/C3MD00394A.
^ Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kieć-Kononowicz K, et al. (August 2016). "Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18". Scientific Reports. 6: 32255. Bibcode:2016NatSR...632255F. doi:10.1038/srep32255. PMC 5004183. PMID 27572937.
^ Schoeder CT, Kaleta M, Mahardhika AB, Olejarz-Maciej A, Łażewska D, Kieć-Kononowicz K, Müller CE (July 2018). "Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18". European Journal of Medicinal Chemistry. 155: 381–397. doi:10.1016/j.ejmech.2018.05.050. PMID 29902723. S2CID 49214747.

[1] Rempel V, Atzler K, Behrenswerth A, Karcz T, Schoeder C, Hinz S, et al. (2014). "Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55". MedChemComm. 5 (5): 632–49. doi:10.1039/C3MD00394A.

[2] Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kieć-Kononowicz K, et al. (August 2016). "Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18". Scientific Reports. 6: 32255. Bibcode:2016NatSR...632255F. doi:10.1038/srep32255. PMC 5004183. PMID 27572937.

[3] Schoeder CT, Kaleta M, Mahardhika AB, Olejarz-Maciej A, Łażewska D, Kieć-Kononowicz K, Müller CE (July 2018). "Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18". European Journal of Medicinal Chemistry. 155: 381–397. doi:10.1016/j.ejmech.2018.05.050. PMID 29902723. S2CID 49214747.

[1]

[2]

[3]

See also

References