GRIK3

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.

GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	OMIM: 138243; MGI: 95816; HomoloGene: 73901; GeneCards: GRIK3; OMA:GRIK3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 36,795,527 bp End 37,034,515 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 58.91 cM Start 125,384,493 bp End 125,607,966 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve spinal ganglia trigeminal ganglion prefrontal cortex primary visual cortex endothelial cell Hypothalamus cingulate gyrus anterior cingulate cortex right frontal lobe Top expressed in median eminence arcuate nucleus lateral septal nucleus Rostral migratory stream lateral hypothalamus ventromedial nucleus mammillary body anterior amygdaloid area paraventricular nucleus of hypothalamus primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kainate selective glutamate receptor activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ion channel activity extracellularly glutamate-gated ion channel activity ligand-gated ion channel activity ionotropic glutamate receptor activity G protein-coupled receptor binding glutamate receptor activity signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction dendrite cytoplasm perikaryon dendrite terminal bouton axon kainate selective glutamate receptor complex presynaptic membrane glutamatergic synapse Biological process G protein-coupled glutamate receptor signaling pathway glutamate receptor signaling pathway ion transport ion transmembrane transport negative regulation of synaptic transmission, glutamatergic ionotropic glutamate receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway regulation of membrane potential excitatory postsynaptic potential synaptic transmission, glutamatergic modulation of chemical synaptic transmission regulation of presynaptic membrane potential regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2899 14807 Ensembl ENSG00000163873 ENSMUSG00000001985 UniProt Q13003 B1AS29 RefSeq (mRNA) NM_000831 NM_001081097 RefSeq (protein) NP_000822 NP_001074566 Location (UCSC) Chr 1: 36.8 – 37.03 Mb Chr 4: 125.38 – 125.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.

See also

• Kainate receptor

Further reading

• Nutt SL, Hoo KH, Rampersad V, et al. (1995). "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites". Recept. Channels. 2 (4): 315–26. PMID 7719709.
• Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. doi:10.1016/S0021-9258(17)32623-6. PMID 8163463.
• Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Schiffer HH, Swanson GT, Masliah E, Heinemann SF (2001). "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains". J. Neurosci. 20 (24): 9025–33. doi:10.1523/JNEUROSCI.20-24-09025.2000. PMC 6773004. PMID 11124978.
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148. S2CID 44474808.
• Begni S, Popoli M, Moraschi S, et al. (2002). "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia". Mol. Psychiatry. 7 (4): 416–8. doi:10.1038/sj.mp.4000987. PMID 11986986.
• Delorme R, Krebs MO, Chabane N, et al. (2004). "Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder". NeuroReport. 15 (4): 699–702. doi:10.1097/00001756-200403220-00025. PMID 15094479. S2CID 29816578.
• Preuss UW, Zill P, Koller G, et al. (2006). "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics". Pharmacogenomics J. 6 (1): 34–41. doi:10.1038/sj.tpj.6500343. PMID 16314883. S2CID 5874096.
• Samochowiec J, Grzywacz A, Kucharska-Mazur J, et al. (2006). "Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence". Neurosci. Lett. 396 (2): 159–62. doi:10.1016/j.neulet.2005.11.030. PMID 16356644. S2CID 23136504.
• Schiffer HH, Heinemann SF (2007). "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 20–6. doi:10.1002/ajmg.b.30374. PMID 16958029.
• Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.

External links

• GRIK3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.