Keratin 10

KRT10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F1Z, 3ASW, 4ZRY
Identifiers
Aliases	KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs	OMIM: 148080; MGI: 96685; GeneCards: KRT10; OMA:KRT10 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,822,614 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,280,190 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; nipple; ; human penis; ; skin of hip; ; skin of abdomen; ; gums; ; gingival epithelium; ; sperm;
	Top expressed in
	skin of external ear; ; lip; ; condyle; ; skin of abdomen; ; umbilical cord; ; skin of back; ; human fetus; ; fossa; ; saccule; ; otic placode;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of skin epidermis; protein heterodimerization activity; protein binding;
Cellular component	cytoplasm; extracellular exosome; intermediate filament; membrane; nucleus; extracellular space; cytosol; cornified envelope; extracellular region; cell surface;
Biological process	keratinocyte differentiation; keratinization; cornification; peptide cross-linking; positive regulation of epidermis development; protein heterotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	3858
	16661
	ENSG00000186395
	ENSMUSG00000019761
	P13645
	P02535
	NM_000421; NM_001379366
	NM_010660
	NP_000412; NP_001366295
	NP_034790
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.^[5]^[6]^[7] Keratin 10 is a type I keratin.

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.^[7]

Interactions

Keratin 10 has been shown to interact with AKT1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186395 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi:10.1111/1523-1747.ep12477087. PMID 2461420.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".
^ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. 21 (21). United States: 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917. PMID 11585925. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Keratin 10

Contents

Function

Interactions

See also

References

Further reading