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Prevalence of sexual dimorphism in mammalian phenotypic traits
- Karp, Natasha A;
- Mason, Jeremy;
- Beaudet, Arthur L;
- Benjamini, Yoav;
- Bower, Lynette;
- Braun, Robert E;
- Brown, Steve DM;
- Chesler, Elissa J;
- Dickinson, Mary E;
- Flenniken, Ann M;
- Fuchs, Helmut;
- Angelis, Martin Hrabe de;
- Gao, Xiang;
- Guo, Shiying;
- Greenaway, Simon;
- Heller, Ruth;
- Herault, Yann;
- Justice, Monica J;
- Kurbatova, Natalja;
- Lelliott, Christopher J;
- Lloyd, KC Kent;
- Mallon, Ann-Marie;
- Mank, Judith E;
- Masuya, Hiroshi;
- McKerlie, Colin;
- Meehan, Terrence F;
- Mott, Richard F;
- Murray, Stephen A;
- Parkinson, Helen;
- Ramirez-Solis, Ramiro;
- Santos, Luis;
- Seavitt, John R;
- Smedley, Damian;
- Sorg, Tania;
- Speak, Anneliese O;
- Steel, Karen P;
- Svenson, Karen L;
- Wakana, Shigeharu;
- West, David;
- Wells, Sara;
- Westerberg, Henrik;
- Yaacoby, Shay;
- White, Jacqueline K
- et al.
Published Web Location
https://doi.org/10.1038/ncomms15475Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
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