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52 stars written in Python
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An opinionated list of awesome Python frameworks, libraries, software and resources.

Python 268,959 26,678 Updated Oct 16, 2025

Uniform Manifold Approximation and Projection

Python 7,997 856 Updated Oct 26, 2025

Single-cell analysis in Python. Scales to >100M cells.

Python 2,254 678 Updated Nov 12, 2025

Unifying Variational Autoencoder (VAE) implementations in Pytorch (NeurIPS 2022)

Python 1,961 178 Updated Jul 31, 2024

Collection of bioinformatics training materials

Python 1,076 192 Updated Oct 26, 2025

RNAseq analysis notes from Ming Tang

Python 1,050 320 Updated Nov 15, 2021

Leave One Feature Out Importance

Python 849 86 Updated Feb 14, 2025

Implementation of the Leiden algorithm for various quality functions to be used with igraph in Python.

Python 703 87 Updated Oct 31, 2025

Gene Set Enrichment Analysis in Python

Python 670 134 Updated Nov 4, 2025

A tool to find sequencing data and metadata from public databases.

Python 592 48 Updated Aug 13, 2024

pySCENIC is a lightning-fast python implementation of the SCENIC pipeline (Single-Cell rEgulatory Network Inference and Clustering) which enables biologists to infer transcription factors, gene reg…

Python 555 197 Updated Jun 26, 2025

Tools for handling Unique Molecular Identifiers in NGS data sets

Python 528 197 Updated Jul 10, 2025

A template repo for Python packages

Python 528 88 Updated Jun 16, 2025

Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics (cell2location model)

Python 387 70 Updated Nov 10, 2025
Python 360 104 Updated Dec 9, 2021

muon is a multimodal omics Python framework

Python 254 32 Updated Nov 10, 2025

Technology-invariant pipeline for spatial omics analysis that scales to millions of cells (Xenium / Visium HD / MERSCOPE / CosMx / PhenoCycler / MACSima / etc)

Python 242 42 Updated Nov 10, 2025

A scanpy extension to analyse single-cell TCR and BCR data.

Python 242 41 Updated Nov 10, 2025

🎼 Integrate multiple high-dimensional datasets with fuzzy k-means and locally linear adjustments.

Python 241 25 Updated Jul 8, 2024

Differential expression analysis for single-cell RNA-seq data.

Python 205 22 Updated Oct 21, 2025

A scalable SCENIC workflow for single-cell gene regulatory network analysis

Python 168 66 Updated Dec 8, 2022

A collection of best practice cookiecutter templates for all domains and languages with extensive Github support ⛺

Python 164 10 Updated Jul 4, 2023

Episcanpy: Epigenomics Single Cell Analysis in Python

Python 148 32 Updated Dec 5, 2024

Fast and accurate in silico inference of HLA genotypes from RNA-seq

Python 147 58 Updated Aug 20, 2024

Subpopulation detection in high-dimensional single-cell data

Python 137 72 Updated Oct 22, 2020

A template for standard compliant snakemake-workflows

Python 115 40 Updated Oct 26, 2025

Python interface to running command-line and web-based MHC binding predictors

Python 99 24 Updated Oct 4, 2024

Cookiecutter template for scverse

Python 85 14 Updated Nov 11, 2025

Subpopulation detection in high-dimensional single-cell data

Python 71 28 Updated Oct 5, 2020

Compute generation probabilities of CDR3 amino acid and nucleotide sequences

Python 62 19 Updated Nov 4, 2025
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