The film started production when Walt Disney was still alive but was not released until after his death.
This was Darleen Carr's first appearance in a feature length movie. She contributed to another Disney movie this same year as the voice of the village girl in The Jungle Book (1967).
Besides the Walt Disney Studios in Burbank, ''Monkeys, Go Home!'' was shot at Disney's Golden Oak Ranch utilizing sets created for the Zorro (1957) TV series.