Cathy seeks a second opinion, causing a strain on her relationship with Dr. Todd; Sean learns about his sister's cancer while adjusting to life with a pregnant Rebecca; Adam sees a therapist against his will.

The talented actors totally transform for their roles. How many do you recognize?

Greatest Character Actors of All Time

IMDb Sr. Video Producer Alex Logan shares 15 of his top picks from TIFF, including Oscar frontrunners, buzzworthy films that deliver the goods, and the latest from his favorite filmmakers.

15 Festival Favorites From Toronto

From [link=/name/nm5097044/]Isabela Merced[/link] to [link=/name/nm6399254/]Tonatiuh[/link], these stars are on the rise.

Hispanic and Latino Stars to Watch

From <a class="ipc-md-link" href="/name/nm5097044/?ref_=tt_eds_right-7_lk">Isabela Merced</a> to <a class="ipc-md-link" href="/name/nm6399254/?ref_=tt_eds_right-7_lk">Tonatiuh</a>, these stars are on the rise.

Cathy Jamison

Paul Jamison

Adam Jamison

Sean Tolkey

Marlene

Rebecca

Dr. Todd Mauer

Dr. Volimer

Brenda

Second Receptionist

Doctor

Cancer Patient

Pedestrian

I'm disowning you as my sister. From now on, we're just neighbors, and good fences make great fucking neighbors.

Laura Linney and John Benjamin Hickey in The Big C (2010)

Laura Linney and Gabriel Basso in The Big C (2010)

John Benjamin Hickey and Cynthia Nixon in The Big C (2010)

Losing Patients

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