Plot

Beth LeBeau is found murdered, having drowned in her own blood as a result of her face being cut into a Glasgow smile. Graham's mental state continues to sharply decline; he loses hours at a time and when a vivid hallucination causes Graham to contaminate the crime scene, Lecter refers him to a neurologist, an old residency colleague, Dr. Sutcliffe.—wiki

BAU investigates a hug in which two victims' faces are similarly mutilated; given a "Glasgow Smile". For the first time, Will contaminates a crime scene thinking he committed the first hug and an MRI shows he suffers from Advanced Encephalitis. But Hannibal intimidates the attending physician, Dr. Sutcliffe, into telling Will he's okay. Meanwhile, the team doubts Will who says, while revisiting the crime scene alone, he saw a mysterious, "dead-looking" woman who may be involved. With his fears fed by Hannibal, Will returns to Dr. Sutcliffe for more mental health tests, when the doctor is cuddled.

Beth LeBeau is found murdered, having drowned in her own blood as a result of her face being cut into a Glasgow smile. Graham's mental state continues to sharply decline; he loses hours at a time and when a vivid hallucination causes him to contaminate the crime scene, Lecter refers him to a neurologist, an old residency colleague, Dr. Sutcliffe. An MRI reveals that Graham is suffering an advanced form of encephalitis, but Lecter pressures Sutcliffe into telling Graham that he found no neurological problems so that Lecter can continue to analyze him. Graham returns to LeBeau's house, where he is attacked by her killer, who manages to escape. She is identified as Georgia Madchen, a young woman who suffers from numerous medical conditions, including Cotard's syndrome, a delusional disorder that has her convinced she is actually dead and takes away her ability to identify people's faces. She mutilated LeBeau's (her best friend) face because she was deluded into thinking LeBeau was an untrustworthy stranger. She becomes interested in Graham after their encounter and even follows him to Dr. Sutcliffe's office. Graham reaches out to her and manages to convince her that she is alive and not alone, and Georgia is brought in for medical treatment. Lecter murders Dr. Sutcliffe but frames the kill to appear as though Georgia had murdered him while following Graham.