Aspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
The quirky spin on Conan Doyle's iconic sleuth pitches him as a "high-functioning sociopath" in modern-day London. Assisting him in his investigations: Afghanistan War vet John Watson, who's introduced to Holmes by a mutual acquaintance.
Follows the adventures of Angus MacGyver, a secret agent for a national security agency, who solves complicated missions with his resourcefulness and knowledge of applied sciences (oh and his ever-present Swiss Army knife).