Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
Aspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
A banker convicted of uxoricide forms a friendship over a quarter century with a hardened convict, while maintaining his innocence and trying to remain hopeful through simple compassion.