Christopher S. Bond Life Sciences Center (MU)
The Christopher S. Bond Life Sciences Center is a major interdisciplinary life sciences research center at MU. It was formed in the mid-1990s with the support of Roger Mitchell, then dean of the College of Agriculture, Food and Natural Resources. Researchers from 12 departments/divisions in six schools and colleges (Colleges of Agriculture, Food and Natural Resources; Arts & Science; Engineering; Human Environmental Sciences; Veterinary Medicine; and the School of Medicine) are housed in the Bond LSC. The Life Sciences Center reports to the Provost through the Office of Research.
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Are there leaks in your product pipeline?
(2010)Successful businesses move new products through the development pipeline swiftly and efficiently. An integral part of this process is the research design and execution. The field of statistics can provide knowledge and ... -
Isolation and characterization of a baculovirus associated with the insect parasitoid wasp, Cotesia marginiventris, or its host, Trichoplusia ni
(University of Wisconsin, 2008)A multiple nucleopolyhedrovirus (MNPV) was isolated from Trichoplusia ni (Hübner) (Lepidoptera: Noctuidae) larvae that had been stung by the parasitoid Cotesia marginiventris (Cresson) (Hymenoptera: Braconidae). The wild ... -
Electrochemical properties of carbon nanoparticles entrapped in silica matrix
(Electrochemical Society, 2008)Carbon-based electrode materials have been widely used for many years for electrochemical charge storage, energy generation, and catalysis. We have developed an electrode material with high specific capacitance by entrapping ... -
Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic ren2 rats
(American Society for Investigative Pathology, 2009)Emerging evidence indicates that impaired mitochondrial fatty acid [beta]-oxidation plays a key role in liver steatosis. We have recently demonstrated that increased angiotensin (ANG) II causes progressive hepatic steatosis ... -
Regulation of floral organ abscission in Arabidopsis thaliana
(The National Academy of Sciences of the USA, 2008)Abscission is a developmental program that results in the active shedding of infected or nonfunctional organs from a plant body. Here, we establish a signaling pathway that controls abscission in Arabidopsis thaliana from ... -
Disseminated chlorellosis in a dog
(American College of Veterinary Pathologists, 2009)An adult dog with ataxia and a lingual mass, previously diagnosed as protothecosis, was euthanized. At the postmortem examination, the lingual mass, regions of the lungs and hilar lymph nodes, liver, mesenteric and sublumbar ... -
Green nanotechnology from tea : phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles
(Royal Society of Chemistry, 2009)Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of ... -
Green nanotechnology from cumin phytochemicals : generation of biocompatible gold nanoparticles
(NIH Public Access, 2009)The powerful antioxidant characteristics of various phytochernicals within cumin prompted us to test their efficacy in reducing sodium tetrachloroaurate to corresponding gold nanoparticles. We, herein, report an unprecedented ... -
Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation
(American Heart Association, 2008)Emerging evidence indicates that mineralocorticoid receptor (MR) blockade reduces the risk of cardiovascular events beyond those predicted by its blood pressure-lowering actions; however, the underlying mechanisms remain ... -
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein
(American Chemical Society, 2007)Human cells are exposed to the electrophilic [alpha],[beta]-unsaturated aldehyde acrolein from a variety of sources. The reaction of acrolein with functionally critical protein thiol residues can yield important biological ... -
Development and assessment of scoring functions for protein identification using PMF data
(Wiley-VCH, 2007)PMF is one of the major methods for protein identification using the MS technology. It is faster and cheaper than MS/MS. Although PMF does not differentiate trypsin-digested peptides of identical mass, which makes it less ... -
Proteomic identification of PKC-mediated expression of 20E-induced protein in Drosophila melanogaster
(ACS, 2007)Ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle protein (USP), are nuclear receptors that mediate the action of the insect molting hormone 20-hydroxyecdysone (20E). There is evidence that the activity ... -
Proteomics of canine lymphoma identifies potential cancer-specific protein markers
(American Association for Cancer Research, 2007)Purpose: Early diagnosis of cancer is crucial for the success of treatment of the disease, and there is a need for markers whose differential expression between disease and normal tissue could be used as a diagnostic tool. ... -
Guest and ligand behavior in zinc-seamed pyrogallol[4]arene molecular capsules
(Wiley-VCH, 2007)Not just an inside job: Encapsulated and confined in an octanuclear zinc-seamed pyrogallol[4]arene molecular capsule, a guest of choice can act as a reporter for electronic communication between the exterior and the interior ... -
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization
(Society for the Study of Reproduction, 2007)The 26S proteasome, which is a multi-subunit protease with specificity for substrate proteins that are postranslationally modified by ubiquitination, has been implicated in acrosomal function and sperm-zona pellucida (ZP) ... -
Cell wall proteome in the maize primary root elongation zone. II. Region-specific changes in water soluble and lightly ionically bound proteins under water deficit
(American Society of Plant Biologists, 2007)Previous work on the adaptation of maize (Zea mays) primary roots to water deficit showed that cell elongation is maintained preferentially toward the apex, and that this response involves modification of cell wall extension ... -
Effect of a single AGE modification on the structure and chaperone activity of human alphaB-Crystallin
(American Chemical Society, 2007)During aging, human lens proteins undergo several post-translational modifications, one of which is glycation. This process leads to the formation of advanced glycation end products (AGEs) which accumulate with time possibly ... -
Accumulation of glial fibrillary acidic protein and histone H4 in brain storage bodies of Tibetan terriers with hereditary neuronal ceroid lipofuscinosis
(Springer Netherlands, 2007)The neuronal ceroid lipofuscinoses (NCLs) are inherited neurodegenerative diseases characterized by massive accumulation of autofluorescent storage bodies in neurons and other cells. A late-onset form of NCL occurs in ... -
Prostaglandins A1 and E1 influence gene expression in an established insect cell line (BCIRL-HzAM1 cells)
(Elsevier, 2007)Prostaglandins (PGs) and other eicosanoids exert important physiological actions in insects and other invertebrates, including influencing ion transport and mediating cellular immune defense functions. Although these actions ... -
Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation
(The American Society for Biochemistry and Molecular Biology, 2008)Analysis of aged and cataract lenses shows the presence of increased amounts of crystallin fragments in the high molecular weight aggregates of water-soluble and water-insoluble fractions. However, the significance of ...