1.6K views · 142 reactions | STOP LISTENING TO MAINSTREAM “EXPERTS!” ⬇️ ⭐️SAVE AND SHARE THIS⭐️ ⭐️⭐️Comment 👉GUIDE👈 for a link to $20 off my guide: The Practical Guide to MTHFR Gene Mutations.⭐️⭐️ There’s been a concerted effort to steer people away from eating protein, especially animal protein, over the past 5-10 years. Some of this is driven by plant-based ideologies. Some of it is rooted in false beliefs about protein, such that it’s hard on the kidneys, causes weight gain, or is bad for the bones, which are all unequivocally disproven. And some of the hype comes from the food industry, which can create far more profitable products when they don’t use animal protein. Yet, it’s the most essential macronutrient in our diet. As it related to MTHFR mutations, eating more protein can do wonders for minimizing the effects of the mutations, from supporting better moods to better detoxifying. So, do not short yourself on protein if you’re dealing with MTHFR issues. 🥩🍖🍳 I generally recommend women consume a MINIMUM of 0.8 grams of protein per pounds goal bodyweight, and men 1.0 grams, minimum. #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
365 reactions · 33 shares | MTHFR vs. COMT ⬇️ ⭐️ SAVE AND SHARE THIS!⭐️ ⭐️⭐️ Comment 👉GUIDE👈 for a link to my Practical Guide to MTHFR Gene Mutations OR 👉COMT👈 for a link to my Practical Guide to COMT Gene Mutations (and $20 off)!⭐️⭐️ WHAT THEY DO ⤵️ ➡️ MTHFR is necessary for methylation and in converting folic acid to methylated folate. 40-60% of the population has polymorphisms which can lead to a plethora of physical and mental health issues (see previous reels on what happens with polymorphisms). ➡️ COMT affects the breakdown of neurotransmitters like dopamine, epinephrine, and norepinephrine. 🔹 Fast COMT variation (Val/Val): Breaks down dopamine and other catecholamines faster, making one better at handling stress but worse with executive function, memory, and cognitive flexibility. 25-30% of population. 🔹 Slow COMT variation (Met/Met): Causes slower neurotransmitter breakdown, leading to better executive and overall cognitive function but more issues with anxiety, stress, and mood disorders. 20-25% of population. 🔹 Balanced COMT: One of each (Val/Met) tend to be more balanced with stress resilience and cognitive function. 45-55% of population. 🔄 People with both MTHFR and COMT mutations might experience compounded effects on mental health, such as increased susceptibility to anxiety, depression, or other mood disorders. #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
2.6K reactions · 31 shares | HOW MTHFR MUTATIONS AFFECT TRAUMA ⬇️ ⭐️SHARE AND SAVE THIS!⭐️ ⭐️⭐️Comment 👉GUIDE👈 for my exact nutrition , lifestyle, and exercise strategy to minimize the effects MTHFR mutations! I couldn’t make this more simple or affordable.⭐️⭐️ When you go through trauma, whether it’s emotional, physical, or psychological, your body and brain launch into survival mode. Hormones spike, inflammation rises, and your nervous system becomes hyper-alert. For most people, the body eventually settles down and begins to repair. But if you have an MTHFR gene mutation, that whole process can get stuck. Here’s why. MTHFR helps convert folate (vitamin B9) into a form your body can actually use called methylfolate. This activated version is crucial for something called methylation, which is like a master control switch for everything from detoxing stress hormones to producing neurotransmitters like serotonin, dopamine, and GABA. If you don’t methylate well: • You may have a harder time clearing out cortisol, so your body stays in fight-or-flight longer. • You produce less serotonin and dopamine, making it tougher to feel emotionally stable or bounce back from sadness or fear. • Your brain might get stuck in “replay mode,” constantly re-living the trauma or feeling emotionally overwhelmed by it. • Your nervous system becomes less resilient…small stressors can feel like huge threats. That’s why some people with MTHFR mutations feel like they just can’t “get over it” the way others do. Their emotional injuries linger longer. And without support, like targeted nutrition, nervous system regulation, and gentle detoxification, they keep reliving the trauma, even when the event is long over. #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach #hormones #gutbrainaxis | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
220 reactions · 65 comments | DO THIS ⬇️ ⭐️SAVE AND SHARE THIS⭐️ ⭐️⭐️Comment 👉GUIDE👈 for my exact nutrition , lifestyle, and exercise strategy to minimize the effects MTHFR mutations, plus a social offer for my COMT guide, too!⭐️⭐️ For BOTH Scenario 1 & 2: ✅ Optimize Folate Intake: Eat plenty of leafy greens (spinach, kale), legumes, and other folate-rich foods. ✅ Support Dopamine Production: Eat protein-rich meals, such as lean meats, fish, eggs, dairy, and high-quality vegan protein powders (if necessary). ✅ Take a high-quality multivitamin, omega-3s, and a good gut-brain axis formula, which are all important for neurotransmitter synthesis. ✅ Exercise regularly to support good neurotransmitter balance Scenario 1 Only ✅ Manage stress by doing activities that help increase dopamine like exciting hobbies and intense exercise ✅ Take multi with methylated B vitamins Scenario 2 Only ✅ Do MODERATE exercise so you don’t overstimulate yourself or cause exhaustion ✅ Keep caffeine intake under 300 mg per day and limit sugar intake ✅ Avoid carb-heavy meals that cause large increases in blood sugar ✅ Take supps with lower levels of methylated B’s and more alternative forms like folinic acid and hydroxycobalamin #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
3.2K views · 166 reactions | WHAT TO DO ⬇️ ⭐️SAVE AND SHARE THIS!⭐️ ⭐️⭐️Follow me, then comment 👉GUIDE👈 Practical Guide to MTHFR Gene Mutations! for my!⭐️⭐️ What to do⤵️ A good diet and lifestyle plan needs to improve your energy levels, boost mood and motivation, support detoxification, and SIGNIFICANTLY improve gut health. AVOID THIS ⤵️ Processed foods, alcohol, artificial sweeteners, environmental toxins ✅ Supplements and foods that contain synthetic folic acid and/or cyanocobalamin ✅ Sleep debt and high intensity exercise if you’re feeling fatigued DO THIS ⤵️ ✅ Eat more leafy greens, legumes, and avocados. This will increase your intake of natural folate. Also, increase your protein intake which supports methylation. ✅ Take a high-quality multivitamin that includes methylfolate and methylcobalamin, fish oil, and, ideally, the Happy Juice stack (comment MTHFR for details). ✅ Moderate-intensity resistance training, walking, and regular use of the sauna are essentail for supporting metabolic function and detoxification, which is hampered with the MTHFR polymorphism. #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach #guthealth #gutbrainaxis #detox | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
848 reactions · 61 shares | THE MTHFR-MCAS CONNECTION ⬇️ ⭐️SAVE AND SHARE THIS!⭐️ ⭐️⭐️Comment 👉GUIDE👈 for my exact nutrition , lifestyle, and exercise strategy to minimize the effects MTHFR mutations! I couldn’t make this more simple or affordable.⭐️⭐️ There’s a clear connection between MTHFR mutations and Mast Cell Activation Syndrome (MCAS) that could help explain why so many people struggle with chronic symptoms like fatigue, brain fog, and unexplained inflammation. MTHFR mutations impair the body’s ability to produce methylfolate, a key player in methylation—a process critical for detoxification, DNA repair, and histamine breakdown. Without efficient methylation, enzymes like HNMT (which help clear histamine) slow down, leaving histamine to accumulate. This creates the perfect storm for mast cells to overactivate, triggering symptoms like flushing, headaches, and gut issues. On top of that, MTHFR mutations often lead to elevated homocysteine levels, driving oxidative stress and chronic inflammation—two major triggers for mast cell activation. Add in factors like gut dysbiosis and stress, both of which can worsen mast cell dysfunction and methylation issues, and it’s easy to see how these conditions feed into each other. So, what can you do? Tackle your MTHFR methylation issues first! ✅Support methylation with a high quality multivitamin with methylated Bs (or bioavailable alternatives if you can’t handle methylated Bs), magnesium, fish oil, D and enzymes - Comment “FOUNDATION” for my recommendations ✅Reduce histamine through diet and natural stabilizers like quercetin and DAO ✅Address oxidative stress with antioxidants. ✅ Eat a higher protein diet and get at least seven hours of sleep every night It’s a complex puzzle, but by addressing these root causes, you can help your body restore balance and calm the cascade of mast cell overactivation. #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
3K views · 151 reactions | WHAT CAN HAPPEN WITH MTHFR MUTATIONS ⬇️ ⭐️ SAVE AND SHARE THIS!⭐️ ⭐️⭐️ Comment 👉GUIDE👈 for a link to my Practical Guide to MTHFR Gene Mutations and an exclusive discount for my IG friends!⭐️⭐️ IF YOU DON’T DO SOMETHING ⬇️ Here’s what you can expect as MTHFR mutations compromise detoxification… 1️⃣ Increased Toxin Load: Over time, the reduced detoxification ability lead to the accumulation of toxins, which contribute to chronic conditions such as fatigue, brain fog, digestive issues, and inflammatory diseases. These toxins can also disrupt endocrine function and increase oxidative stress. 2️⃣ Hormonal Imbalance: An impaired detoxification system can lead to imbalances in estrogen, thyroid hormones, and other key hormones, potentially worsening conditions like PCOS, endometriosis, and hypothyroidism. 3️⃣ Elevated Homocysteine Levels: The methylation cycle’s disruption causes elevated homocysteine. High homocysteine levels are linked to a higher risk of stroke, heart attack, and other vascular diseases. 4️⃣ Neurological Issues: Homocysteine and toxin buildup increases the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s, as well as mood disorders such as anxiety, depression, or ADHD. 5️⃣ Immune System Dysfunction: A poorly functioning detox system can cause chronic immune activation, leading to conditions such as autoimmune diseases. With a higher toxin load, your immune system may become overwhelmed, triggering inflammation and immune dysfunction. 6️⃣ Gut Dysfunction: MTHFR mutations affect gut function indirectly by contributing to a buildup of toxins that impair gut barrier integrity, lead to dysbiosis, and increase the risk of conditions like leaky gut, which further complicates detoxification. If this ever feels too overwhelming, comment “CONSULT” and book a one-on-one session with me! #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach #hormones #gutbrainaxis | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
2.2K views · 134 reactions | WHAT HAPPENS WITH BETTER GUT HEALTH ⬇️ ⭐️SAVE AND SHARE THIS⭐️ ⭐️⭐️Comment 👉MTHFR👈 for the details on the best, patented, science-based gut-brain system on the planet.⭐️⭐️ I realize the first recommendation for those with MTHFR mutations is to increase natural folate (methyltetrahydrofolate). However, you can actually produce your own B vitamins when you have a healthy gut. Not only that, but a healthy gut helps you avoid many of the other health issues MTHFR mutations are known for, such as: • problems with detoxification • systemic inflammation • increased homocysteine • leaky gut and autoimmune issues • mental wellness challenges like anxiousness or occasional feelings of depression. If you think you have MTHFR issues, get your gut right and you might find any of the related symptoms go away. Want to get access to my complete MTHFR program? Comment “GUIDE” for info and an exclusive discount! #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach #hormones #thyroidhealth #gutbrainaxis #guthealth | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
439 reactions · 70 shares | It all made sense once I discovered MTHFR runs in my family ….the gallbladder disease, fatty liver, obesity, mental illness, OCD…..It was all related to blocked methylation and synthetic folic acid. And I was heading down the same path - fatty liver, gallstones, extra weight and depression. ✨But by the grace of God I was led to MTHFR. 👉If you have one or more of these, there’s a pretty good chance that you have an MTHFR variation that runs in your family too. The biggest problem for those with MTHFR? Synthetic folic acid (low quality form of folate, B9). Synthetic folic acid can slow/block methylation and cause BIG problems if you have an MTHFR variation, MTHFR is an enzyme that helps to: -Make bile -Make neurotransmitters (mental health) -Detoxify estrogen, cortisol and heavy metals -Help absorb fat soluble nutrients -Repair DNA and cells -Make new red blood cells -Maintain gut health -Reduce inflammation So if methylation is slow or impaired, it can lead to a cascade of health issues. Think you might have an MTHFR variation? Comment “guide” for my free MTHFR guide to learn more about the common signs, bloodwork markers, testing and first steps to feeling better. #fattyliverhelp #nafld #mthfr #mthfrsupport #nogallbladderproblems #gallbladderremoved #nafldhelp #womenshealth #womensnutrition #perimenopauseweightloss #metabolismtipsforwomen | Lisa | Liver, MTHFR & Metabolism Coach | Facebook
1K reactions · 35 shares | DON’T MAKE THESE MISTAKES ⬇️ ⭐️SAVE AND SHARE THIS!⭐️ ⭐️⭐️Comment 👉GUIDE👈 for my Practical Guide to MTHFR Mutations, an exact plan to minimize this impact of MTHFR Gene Mutations!⭐️⭐️ I’ve worked SO MANY PEOPLE this past year who’ve gotten really bad advice from social media influencers and health coaches about dealing with MTHFR. Many end up megadosing on B vitamins (which often leads to anxiety) while others resort to a plant-based diet with minimal protein. Still others avoid exercise altogether because they’re exhausted, while some think high-intensity exercise is what they need. Interestingly, that often leads to higher anxiety and lower stress resilience, as well. The reality is, with the right approach to nutrition, exercise, and lifestyle, you can end up healthier, fitter, and mentally stronger than most people without the mutations. Eat, supplement and live in a way that builds and maintains muscle, supports detoxification, enhances gut health, and reduces neuroinflammation (that’s the idea with the plan I lay out in my guide). If you do that, you end up with a gut that absorbs and produces B vitamins better, a system that rids the body of toxins that compromise your physical and mental health, and a body with more muscle that keeps blood sugar levels and your mood more stable. And it won’t take long…within a few months you’ll be feeling like a new person! #cortisol #stress #cortisolcontrol #fatigue #fitness #weightloss #nutritioncoach #personaltrainer #mentalwellness #fitnesstips #fitnessmotivation #GABA #cravings #dopamine #serotonin #mentalfitness #cortisolcoach #wellnesscoach | Tom Nikkola, CSCS | Personal Trainer, Nutrition Coach | Facebook
14K views · 198 reactions | Dr. Don Colbert, MD explains how this common genetic mutation affects neurotransmitters like dopamine, norepinephrine, and serotonin — and why it can be linked to: 🧠 Major Depression 🧠 Bipolar Disorder 🧠 Schizophrenia 🧠 Anxiety 🧠 ADHD 🧠 Autism 👨⚕️ How to test for MTHFR? ✔️ Simple blood test (~$100) – available at most labs ✔️ At-home options (like buccal swab kits) ✔️ Ancestry or 23andMe + GeneticGenie interpretation ✔️ Ask your doctor or order online for convenience 👉 Dr. Colbert recommends testing all grandkids and family members — because early detection can make a huge difference in mood, focus, and long-term health. 📲 Follow for more life-changing insights from Dr. Colbert — physician, bestselling author, and integrative health expert. #MTHFR #DrColbert #MentalHealthMatters #GeneticTesting #FaithAndHealth #ADHD #AnxietyHelp #DepressionAwareness #FunctionalMedicine #ChristianDoctor #DivineHealth | Dr. Don Colbert | Facebook
The Best Diet for MTHFR and Weight Loss - Foods to Eat and Foods to Avoid
Eating foods high in folate and vitamin B2 is the best MTHFR diet if someone has the MTHFR gene mutation as the function of the MTHFR gene is to convert folate into the active form called methylfolate. For the MTHFR enzyme to function and convert folate into methylfolate the MTHFR gene requires vitamin B2 as a co-factor which is why it is crucial for someone with an MTHFR gene mutation to eat foods high in folate and B2.