Welcome to PDB-IHM
PDB-IHM is a system for archiving structural models obtained using integrative or hybrid modeling, managed by the wwPDB and funded by the NSF, DOE, and NIH. Structural characterization of many complex macromolecular assemblies is increasingly carried out using integrative modeling, where a combination of complementary experimental and computational techniques is used to determine the structure. The structural models obtained through integrative modeling are collected, processed, and disseminated to the public through PDB-IHM. PDB-IHM was recently unified with the PDB archive, serving integrative structures alongside experimental structures. Integrative structures are now provided PDB accession codes and can be accessed from the PDB archive and wwPDB.
Released PDB-IHM Structures
RNF168-RING domain and nucleosome complex
Release Date: 2019-04-29
Publication doi: 10.1038/s41467-019-09756-z
Myeloid-derived growth factor with KDEL receptor
Release Date: 2019-12-18
Publication doi: 10.1038/s41467-019-13577-5
News
PDB-IHM Publication
Recent updates to PDB-IHM, including the unification with the PDB archive, have been published in the Journal of Molecular Biology: Vallat B et al., PDB-IHM: A System for Deposition, Curation, Validation, and Dissemination of Integrative Structures, J Mol Biol. 2025; 168963. doi: 10.1016/j.jmb.2025.168963. Read more...
IHM Validation Software Version 2 Supports Crosslinking-MS data
Version 2 (V2) of the IHM Validation software has been released. The updated validation software has been implemented into the PDB-IHM deposition and data harvesting system and V2 validation reports have been regenerated and made publicly available for all released entries. The updated version extends IHM validation to include structures obtained from Chemical Crosslinking Mass Spectrometry (Crosslinking-MS) data, in addition to previously supported Small Angle Scattering (SAS) data. Collaborating with the Crosslinking-MS community, mechanisms for interoperating with the PRIDE repository have been developed to enable validation of structures based on Crosslinking-MS. Read more...
PDB-Dev rebranded as PDB-IHM
In August 2024, PDB-Dev was unified with the PDB to deliver integrative structures alongside archived experimental structures in the PDB archive. Following the unification, PDB-Dev has now been rebranded as PDB-IHM. Read more...
wwPDB DOIs and DOI Landing Pages for Integrative Structures
Integrative structures are now available at wwPDB Digitial Object Identifier (DOI) landing pages, along with >225,000 experimental structures in the PDB archive. DOI landing pages are available for both released and on-hold entries in PDB-IHM. Read more...
Integrative Structures in the PDB Archive
Structures determined by integrative and hybrid structure determination methods (IHM) are now available alongside experimental structures in the PDB archive. Users can access and download IHM structures and associated data from the PDB archive. Currently, holding files in JSON format, validation reports (summary and full reports) in PDF format, and model files in PDBx/mmCIF format are provided. Read more...