Name	Known for
Ellen Pompeo Dr. Meredith Grey Dr. Meredith Grey See fewer	Grey's Anatomy (2005)
Sandra Oh Dr. Cristina Yang Dr. Cristina Yang See fewer	Killing Eve (2018)
Katherine Heigl Dr. Izzie Stevens Dr. Izzie Stevens See fewer	One for the Money (2012)
Justin Chambers Dr. Alex Karev Dr. Alex Karev See fewer	Grey's Anatomy (2005)
T.R. Knight Dr. George O'Malley Dr. George O'Malley See fewer	The Flight Attendant (2020)
Chandra Wilson Dr. Miranda Bailey Dr. Miranda Bailey See fewer	Grey's Anatomy (2005)
James Pickens Jr. Dr. Richard Webber Dr. Richard Webber See fewer	Grey's Anatomy (2005)
Kate Walsh Dr. Addison Montgomery Dr. Addison Montgomery See fewer	The Perks of Being a Wallflower (2012)
Sara Ramirez Dr. Callie Torres Dr. Callie Torres See fewer	Grey's Anatomy (2005)
Eric Dane Dr. Mark Sloan Dr. Mark Sloan See fewer	X-Men: The Last Stand (2006)
Isaiah Washington Dr. Preston Burke Dr. Preston Burke See fewer	Grey's Anatomy (2005)
Patrick Dempsey Dr. Derek Shepherd Dr. Derek Shepherd See fewer	Grey's Anatomy (2005)
Faith Prince Sonya Cowlman Sonya Cowlman See fewer	The Last Dragon (1985)
Arye Gross Adam Morris Adam Morris See fewer	Better Call Saul (2015)
Justina Machado Anna Nyles Anna Nyles See fewer	Torque (2004)
Chris Conner Mr. Nyles Mr. Nyles See fewer	Horizon: An American Saga - Chapter 2 (2024)
Margo Harshman Jennifer Morris Jennifer Morris See fewer	Fired Up! (2009)
Todd Babcock Dr. Matthew Savoy Dr. Matthew Savoy See fewer	Planet of the Apes (2001)
Moe Irvin Nurse Tyler Nurse Tyler See fewer	Ahsoka (2023)
Kate Anthony Nurse Kate Nurse Kate See fewer	Grey's Anatomy (2005)
Karl T. Wright Mediator Mediator See fewer	Atypical (2017)
Libby Barnes Dr. #1 Dr. #1 See fewer	Grey's Anatomy (2005)
Tom Ormeny Dr. #2 Dr. #2 See fewer	Gang Related (1997)
Bokhee An Nurse Bokhee (uncredited) Nurse Bokhee (uncredited) See fewer	Grey's Anatomy (2005)