Thalassemia Syndrome Mnemonic "THAL"
Eachindividual carries 4 functional alpha chain genes and 2 functional beta chain genes. Alpha and beta-thalassemia are inherited disorders in which there is reduced production of alpha-globin or beta-globin chains, respectively ✓Alpha thalassemia: Gene deletion is the most common cause of reduced a-chain synthesis, ✓Beta +- thalassemia: The most common cause is splicing mutation. ✓Beta 0- thalassemia: Chain terminator mutations are the most common cause
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