Frontiers | Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes
In conclusion, our study revealed the promotive role of TMAO in demyelination of corpus callosum regions, contributing to lesions in white matter of spontaneously hypertensive rats. And TMAO mainly resulted in the pyroptosis of oligodendrocytes to promote the development of demyelination through mitochondrial dysfunction and ROS/NLRP3 pathway. These findings might identify the potential targets for therapeutic intervention and provide new insight into the effect of TMAO in hypertension-induced
Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies
Cerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its clinical expression is highly varied, and prognostic implications are frequently overlooked in clinics; thus, treatment is currently confined to vascular risk factor management. Traditionally, SVD is considered the small vessel equivalent of large artery stroke (occlusion, rupture), but data emerging from human ...
Tim Rees on Twitter
Tim Rees on Twitter: "I'm going to war against #tinnitus. I haven't had the energy to attack it yet, but now that's correcting I'm devising a battle plan. My initial thoughts are high levels of #homocysteine causing nerve damage et al. I'll be adding to this MM as I research & n=1 #mthfr https://t.co/uRCwbUwOK2" / Twitter
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Neuroscience News on Twitter: "Regular exercise may slow decline in those at risk of Alzheimer's An indicator of the Alzheimer’s, known as white matter hyperintensities, significantly increased in the brain with age, but not so much in participants with high levels of aerobic fitness. https://t.co/OSp7YeAnaR" / Twitter
Neuroscience News on Twitter
Neuroscience News on Twitter: "Regular exercise may slow decline in those at risk of Alzheimer's An indicator of the Alzheimer’s, known as white matter hyperintensities, significantly increased in the brain with age, but not so much in participants with high levels of aerobic fitness. https://t.co/OSp7YeAnaR" / Twitter
Neuroscience News on Twitter
Neuroscience News on Twitter: "Regular exercise may slow decline in those at risk of Alzheimer's An indicator of the Alzheimer’s, known as white matter hyperintensities, significantly increased in the brain with age, but not so much in participants with high levels of aerobic fitness. https://t.co/OSp7YeAnaR" / Twitter
Effect of Antihypertensives by Class on Cerebral Small Vessel Disease: A Post Hoc Analysis of SPRINT-MIND | Stroke
Background: Treatment of uncontrolled arterial hypertension reduces the risk of cerebral small vessel disease (CSVD) progression, although it is unclear whether this reduction occurs due to blood pre
Trimethylamine N-Oxide: The Good, the Bad and the Unknown
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing ...
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