Seeing repeated numbers is a sign that the universe is trying to communicate with you. Each angel number carries a hidden message with itself. So, what does seeing 4545 Angel Number means? 4545 signifies your understanding of life. It is a sign from the Universe to let the Guardian Angels clean your soul. The meaning of seeing 4545 angel number denotes that you are a spiritual being that can manifest wealth, love, luck, prosperity whatever it is that you desire.