Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation

…, G Liu, PK Moore, X Wang, H Wang, Z Zhang… - Diabetes, 2016 - Am Diabetes Assoc
Hydrogen sulfide (H 2 S) has been shown to have powerful antioxidative and anti-inflammatory
properties that can regulate multiple cardiovascular functions. However, its precise role …

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

…, R Shi, YQ Liu, Y Liu, M Jiang, Y Wu, Z Zhang - Nature …, 2016 - nature.com
Inflammation resolution is an active process, the failure of which causes uncontrolled
inflammation which underlies many chronic diseases. Therefore, endogenous pathways that …

Erythropoeitin signaling in macrophages promotes dying cell clearance and immune tolerance

…, Z Shen, J Wang, R Shi, Y Liu, Y Liu, M Jiang, Z Zhang… - Immunity, 2016 - cell.com
The failure of apoptotic cell clearance is linked to autoimmune diseases, nonresolving
inflammation, and developmental abnormalities; however, pathways that regulate phagocytes for …

Oxidative burst of circulating neutrophils following traumatic brain injury in human

Y Liao, P Liu, F Guo, ZY Zhang, Z Zhang - PloS one, 2013 - journals.plos.org
Besides secondary injury at the lesional site, Traumatic brain injury (TBI) can cause a
systemic inflammatory response, which may cause damage to initially unaffected organs and …

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains

Z Zhang, ZY Zhang, J Schittenhelm, Y Wu… - Journal of …, 2011 - Elsevier
Reactive macrophages/microglia exert both protective or damaging effects in multiple sclerosis
(MS), which contribute to the relapsing–remitting nature of MS. CD163 is considered a …

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with …

Z Zhang, ZY Zhang, HJ Schluesener - The Journal of Immunology, 2009 - journals.aai.org
Experimental autoimmune neuritis (EAN) is a helper T cell-mediated autoimmune demyelinating
inflammatory disease of the peripheral nervous system and serves as the animal model …

Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth

…, P Zheng, B Dong, F Shao, X Qian, R Yu, Z Zhang… - Nature cell …, 2023 - nature.com
Impairment of the circadian clock is linked to cancer development. However, whether the
circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we …

Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways

Y Zhang, JH Wang, YY Zhang, YZ Wang, J Wang… - Scientific reports, 2016 - nature.com
Interleukin 6 (IL-6) has been shown to be an important regulator of cardiac interstitial fibrosis.
In this study, we explored the role of interleukin-6 in the development of diabetic …

SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm

…, Z Sun, J Cao, Z Wang, Y Wang, B Yu, Z Zhang… - The Journal of Clinical …, 2024 - jci.org
Aortic aneurysm is a life-threatening disease with limited interventions that is closely related
to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, a member of the …