Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation
Hydrogen sulfide (H 2 S) has been shown to have powerful antioxidative and anti-inflammatory
properties that can regulate multiple cardiovascular functions. However, its precise role …
properties that can regulate multiple cardiovascular functions. However, its precise role …
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
…, R Shi, YQ Liu, Y Liu, M Jiang, Y Wu, Z Zhang - Nature …, 2016 - nature.com
Inflammation resolution is an active process, the failure of which causes uncontrolled
inflammation which underlies many chronic diseases. Therefore, endogenous pathways that …
inflammation which underlies many chronic diseases. Therefore, endogenous pathways that …
Erythropoeitin signaling in macrophages promotes dying cell clearance and immune tolerance
…, Z Shen, J Wang, R Shi, Y Liu, Y Liu, M Jiang, Z Zhang… - Immunity, 2016 - cell.com
The failure of apoptotic cell clearance is linked to autoimmune diseases, nonresolving
inflammation, and developmental abnormalities; however, pathways that regulate phagocytes for …
inflammation, and developmental abnormalities; however, pathways that regulate phagocytes for …
Oxidative burst of circulating neutrophils following traumatic brain injury in human
Y Liao, P Liu, F Guo, ZY Zhang, Z Zhang - PloS one, 2013 - journals.plos.org
Besides secondary injury at the lesional site, Traumatic brain injury (TBI) can cause a
systemic inflammatory response, which may cause damage to initially unaffected organs and …
systemic inflammatory response, which may cause damage to initially unaffected organs and …
Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains
Z Zhang, ZY Zhang, J Schittenhelm, Y Wu… - Journal of …, 2011 - Elsevier
Reactive macrophages/microglia exert both protective or damaging effects in multiple sclerosis
(MS), which contribute to the relapsing–remitting nature of MS. CD163 is considered a …
(MS), which contribute to the relapsing–remitting nature of MS. CD163 is considered a …
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with …
Z Zhang, ZY Zhang, HJ Schluesener - The Journal of Immunology, 2009 - journals.aai.org
Experimental autoimmune neuritis (EAN) is a helper T cell-mediated autoimmune demyelinating
inflammatory disease of the peripheral nervous system and serves as the animal model …
inflammatory disease of the peripheral nervous system and serves as the animal model …
Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth
Impairment of the circadian clock is linked to cancer development. However, whether the
circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we …
circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we …
Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways
Y Zhang, JH Wang, YY Zhang, YZ Wang, J Wang… - Scientific reports, 2016 - nature.com
Interleukin 6 (IL-6) has been shown to be an important regulator of cardiac interstitial fibrosis.
In this study, we explored the role of interleukin-6 in the development of diabetic …
In this study, we explored the role of interleukin-6 in the development of diabetic …
SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm
…, Z Sun, J Cao, Z Wang, Y Wang, B Yu, Z Zhang… - The Journal of Clinical …, 2024 - jci.org
Aortic aneurysm is a life-threatening disease with limited interventions that is closely related
to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, a member of the …
to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, a member of the …