Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Cancers develop in complex tissue environments, which they depend on for sustained
growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor …

Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …

The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis but also has profound effects on therapeutic efficacy. In the case of …

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …

INTRODUCTION Fibroblasts are the predominant cell type that synthesizes and remodels
the extracellular matrix in organs during both embryonic and adult life and are central to the …

Cancer is a leading cause of death worldwide. The burden of cancer incidence and mortality
is increasing rapidly. New approaches to cancer prevention and treatment are urgently …