In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

Tissue engineering and regenerative medicine have shown potential in the repair and
regeneration of tissues and organs via the use of engineered biomaterials and scaffolds …

In this study, we investigated the mechanisms by which puerarin alleviates osteoclast-
related loss of bone mass in ovariectomy (OVX)-induced osteoporosis model mice. Puerarin …

Postmenopausal osteoporosis (OP) is one of the most common bone diseases that affects
millions of aging women. Reduced osteogenesis and increased oxidative stress have been …

Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of
breast cancer (BC). The ECM comprises of highly variable and dynamic components …

Reactive oxygen species (ROS) are implicated in induction of inflammatory response and
cartilage degradation in osteoarthritis (OA). Melatonin has been shown to improve the …

Introduction The bone regeneration of endosseous implanted biomaterials is often impaired
by the host immune response, especially macrophage-related inflammation which plays an …

Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair,
because GO can not only enhance the mechanical properties of polymers but also promote …

Cellular senescence is a major hurdle for primary cell-based tissue engineering and
regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes …

Energy metabolism is the process of generating energy (ie ATP) from nutrients. This process
is indispensable for cell homeostasis maintenance and responses to varying conditions …