Since the advent of HAART, patients with HIV infection have seen a significant improvement
in their morbidity, mortality, and life expectancy. The incidence of AIDS-defining illnesses, …

Entinostat is a synthetic benzamide derivative histone deacetylase (HDAC) inhibitor, which
potently and selectively inhibits class I and IV HDAC enzymes. This action promotes histone …

Highly active antiretroviral therapy (HAART) has substantially reduced morbidity and
mortality of AIDS-related complications in patients with HIV; however, the prevalence of AIDS-…

Epigenetic alterations are strongly associated with the development of cancer. We conducted
a phase I/II trial of combined epigenetic therapy with azacitidine and entinostat, inhibitors …

… from 25 to 75 mg/m 2 /d; the mean ± SD C max and AUC 0-8 at 25 mg/m 2 /d were 1,612 ±
1,042 nmol/L and 1,941 ± 980 h × nmol/L, respectively, and at 75 mg/m 2 /d was 6,207 nmol/L …

Patients received 5-azacytidine (AZA) 75 mg/m 2 intravenously daily for 7 days and sorafenib
400 mg orally twice daily continuously; cycles were repeated at ∼1-month intervals. Forty-…

Purpose: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an
important clinical problem, but its underlying mechanisms are largely unknown. We analyzed …

We define the activity and mechanisms of action of a small molecule lead compound for
cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic …

The fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation is associated
with a high relapse rate for patients with acute myeloid leukemia (AML) even after …

Curcumin or diferuloylmethane is a yellow polyphenol extracted from the rhizome of turmeric
(Curcuma longa). A large volume (several hundreds) of published reports has established …