Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Importance It is unknown whether intravenous thrombolysis using tenecteplase is noninferior
or preferable compared with alteplase for patients with acute ischemic stroke. Objective To …

Background and Purpose: There is interest in what happens over time to the thrombus after
intravenous alteplase. We study the effect of alteplase on thrombus structure and its impact …

Purpose Use of automated perfusion software has gained importance for imaging of stroke
patients for mechanical thrombectomy (MT). We aim to compare four perfusion software …

Background Individuals with minor ischaemic stroke and intracranial occlusion are at
increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve …

Selective therapeutic hypothermia in the setting of mechanical thrombectomy (MT) is promising
to further improve the outcomes of large vessel occlusion stroke. A significant limitation in …

Background: Early ischemic changes on baseline imaging are commonly evaluated for
acute stroke decision-making and prognostication. Aims: We assess the association of early …

BACKGROUND AND PURPOSE: The presence of spot sign is associated with a high risk of
hematoma growth. Our aim was to investigate the timing of the appearance, volume, and …

Background: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15–20%
of acute stroke with large vessel occlusion. Aims: We investigated the safety and efficacy of …

Background and purpose The ANNEXA‐4 trial measured hemostatic efficacy of andexanet
alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was …