Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

M Leclerc, E Voilin, G Gros, S Corgnac… - Nature …, 2019 - nature.com
Neuropilin-1 (Nrp-1) is a marker for murine CD4 + FoxP3 + regulatory T (Treg) cells, a
subset of human CD4 + Treg cells, and a population of CD8 + T cells infiltrating certain solid …

Recent advances in lung cancer immunotherapy: Input of T-cell epitopes associated with impaired peptide processing

M Leclerc, L Mezquita, G Guillebot De Nerville… - Frontiers in …, 2019 - frontiersin.org
Recent advances in lung cancer treatment are emerging from new immunotherapies that
target T-cell inhibitory receptors, such as programmed cell death-1 (PD-1). However, …

CD103+ CD8+ TRM cells accumulate in tumors of anti-PD-1-responder lung cancer patients and are tumor-reactive lymphocytes enriched with Tc17

…, L Grynszpan, N Signolle, T Dayris, M Leclerc… - Cell Reports …, 2020 - cell.com
Accumulation of CD103 + CD8 + resident memory T (T RM ) cells in human lung tumors has
been associated with a favorable prognosis. However, the contribution of T RM to anti-tumor …

TGFβ signaling intersects with CD103 integrin signaling to promote T-lymphocyte accumulation and antitumor activity in the lung tumor microenvironment

M Boutet, L Gauthier, M Leclerc, G Gros… - Cancer research, 2016 - AACR
Homing of CD8 + T lymphocytes to the tumor microenvironment is an important step for mounting
a robust antitumor immune response. TGFβ is responsible for CD103 (α E β 7 ) integrin …

Multi-scale patterns in the structure of fish and fouling communities associated with seaweeds in marinas

JC Leclerc, M Gonzalez, JP Pezy, A Raoux… - Marine Ecology …, 2024 - int-res.com
Redistribution of biodiversity represents a key challenge for understanding scales of spatial
variation in natural marine communities. With increasing coastal urbanization, artificial …

Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death

…, V Picant, M Serra, M Leclerc… - PLoS computational …, 2021 - journals.plos.org
The emerging tumor-on-chip (ToC) approaches allow to address biomedical questions out
of reach with classical cell culture techniques: in biomimetic 3D hydrogels they partially …

Habitat type drives the distribution of non‐indigenous species in fouling communities regardless of associated maritime traffic

JC Leclerc, F Viard… - Diversity and …, 2020 - Wiley Online Library
… Here, we show that regardless of the type of maritime traffic, marine artificial habitats are
not equally prone to NIS spread and to biotic homogenization at regional scale (Figure 4). …

Distribution of functionally distinct native and non‐indigenous species within marine urban habitats

J Leclerc, NN Figueroa, F Viard… - Diversity and …, 2023 - Wiley Online Library
… The species data set used in this study comes from Leclerc, Viard, González-Sepúlveda,
et al. (2020). These authors examined the diversity and community structure of 3- and 13-…

Large seafloor rupture caused by the 1956 Amorgos tsunamigenic earthquake, Greece

F Leclerc, S Palagonia, N Feuillet, P Nomikou… - … Earth & Environment, 2024 - nature.com
In the Mediterranean Sea, the probability that a large earthquake-triggered tsunami will
occur in the coming decades is high. Historical tsunami database informs us on their …

The reef platform of Martinique: Interplay between eustasy, tectonic subsidence and volcanism since Late Pleistocene

F Leclerc, N Feuillet, M Perret, G Cabioch, S Bazin… - Marine Geology, 2015 - Elsevier
Reef positions record the interaction between eustasy and tectonics, and have been used
worldwide to characterize vertical deformations of upper-plates at different time-scales and …