Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide
…, E Kilic, RT Al-Jamal, I Dianzani, M Betti… - JNCI: Journal of the …, 2018 - academic.oup.com
Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS)
is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
[HTML][HTML] Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma
M Betti, E Casalone, D Ferrante, A Aspesi, G Morleo… - Cancer letters, 2017 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos
exposure. An inherited predisposition has been suggested to explain multiple cases in the …
exposure. An inherited predisposition has been suggested to explain multiple cases in the …
Clinical portrait of the SARS-CoV-2 epidemic in European patients with cancer
…, C Tondini, O Mirallas, V Tovazzi, M Betti… - Cancer …, 2020 - aacrjournals.org
In this observational study of 890 patients with cancer diagnosed with SARS-CoV-2, mortality
was 33.6% and predicted by male gender, age ≥65, and comorbidity burden. Delivery of …
was 33.6% and predicted by male gender, age ≥65, and comorbidity burden. Delivery of …
Outcomes of the SARS-CoV-2 omicron (B. 1.1. 529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the …
…, A Marrari, S Delfanti, A Maconi, M Betti… - The Lancet …, 2022 - thelancet.com
Background The omicron (B.1.1.529) variant of SARS-CoV-2 is highly transmissible and
escapes vaccine-induced immunity. We aimed to describe outcomes due to COVID-19 during …
escapes vaccine-induced immunity. We aimed to describe outcomes due to COVID-19 during …
Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients
…, M Bertoli, S Bertolin, M Bertolotti, M Betti… - Scientific reports, 2020 - nature.com
Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely
among different countries and during different phases of the pandemia. Here, we aimed to …
among different countries and during different phases of the pandemia. Here, we aimed to …
Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes
M Betti, A Aspesi, D Ferrante, M Sculco… - Genes …, 2018 - Wiley Online Library
Pathogenic germline variants in the BAP1 tumor suppressor gene can cause a cancer
syndrome called BAP1 tumor predisposition syndrome (BAP1‐TPDS), which is characterized by …
syndrome called BAP1 tumor predisposition syndrome (BAP1‐TPDS), which is characterized by …
CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma
M Betti, A Aspesi, A Biasi, E Casalone, D Ferrante… - Cancer letters, 2016 - Elsevier
BAP1 germline mutations predispose to a cancer predisposition syndrome that includes
mesothelioma, cutaneous melanoma, uveal melanoma and other cancers. This co-occurrence …
mesothelioma, cutaneous melanoma, uveal melanoma and other cancers. This co-occurrence …
Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high‐risk area
M Betti, E Casalone, D Ferrante… - Genes …, 2015 - Wiley Online Library
Inherited loss‐of‐function mutations in the BAP1 oncosuppressor gene are responsible for
an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and …
an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and …
[HTML][HTML] Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer
…, A Marrari, F Grosso, A Maconi, M Betti… - European Journal of …, 2022 - Elsevier
Background Although SARS-CoV-2 vaccines immunogenicity in patients with cancer has
been investigated, whether they can significantly improve the severity of COVID-19 in this …
been investigated, whether they can significantly improve the severity of COVID-19 in this …
Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare
aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, …
aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, …