Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness
of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic …

Mutations play a fundamental role in the development of cancer, and many create
targetable vulnerabilities. There are both public health and basic science benefits from the …

Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense
fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to …

Background YB-1 is a multifunctional protein that affects transcription, splicing, and translation.
Overexpression of YB-1 in breast cancers causes cisplatin resistance. Recent data have …

Background Recent advances in the treatment of cancer have focused on targeting genomic
aberrations with selective therapeutic agents. In radioiodine resistant aggressive papillary …

Background Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer characterized
by complex aberrant genomes. A fundamental goal of current studies is to identify those …

Background Mathematical/computational models are needed to understand cell signaling
networks, which are complex. Signaling proteins contain multiple functional components and …

Proteins in cell signaling networks tend to interact promiscuously through low-affinity interactions.
Consequently, evaluating the physiological importance of mapped interactions can be …

Medulloblastoma, the most common malignant brain tumor in children, occurs with increased
frequency in individuals with Fanconi anemia who have biallelic germline mutations in …

To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation
in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the …