The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

Purpose Combining tumor antigens with an immunostimulant can induce the immune system
to specifically eliminate cancer cells. Generally, this combination is accomplished in an ex …

Inferring precise phenotypic patterns from population-scale clinical data is a core computational
task in the development of precision, personalized medicine. The traditional approach …

Objectives Drug repurposing, which finds new indications for existing drugs, has received
great attention recently. The goal of our work is to assess the feasibility of using electronic …

Background Patients, clinicians, researchers and payers are seeking to understand the
value of using genomic information (as reflected by genotyping, sequencing, family history or …

The scale of tumor genomic profiling is rapidly outpacing human cognitive capacity to make
clinical decisions without the aid of tools. New frameworks are needed to help researchers …

Background To realize potential public health benefits from genetic and genomic innovations,
understanding how best to implement the innovations into clinical care is important. The …

Importance The most useful biomarkers for clinical decision-making identify patients likely to
have improved outcomes with one treatment vs another. Objective To evaluate treatment …

Identification of a cohort of patients with specific diseases is an important step for clinical
research that is based on electronic health records (EHRs). Informatics approaches combining …

The rise of genomically targeted therapies and immunotherapy has revolutionized the
practice of oncology in the last 10–15 years. At the same time, new technologies and the …