User profiles for Mike Clark

Mike Clark

Retired (30th Sept 2014) as Reader in Therapeutic and Molecular Immunology, Cambridge …
Verified email at cam.ac.uk
Cited by 12171

On the effectiveness of secret key extraction from wireless signal strength in real environments

S Jana, SN Premnath, M Clark, SK Kasera… - Proceedings of the 15th …, 2009 - dl.acm.org
We evaluate the effectiveness of secret key extraction, for private communication between
two wireless devices, from the received signal strength (RSS) variations on the wireless …

Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities

KL Armour, MR Clark, AG Hadley… - European journal of …, 1999 - Wiley Online Library
Subclasses of human IgG have a range of activity levels with different effector systems but
each triggers at least one mechanism of cell destruction. We are aiming to engineer non‐…

Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation

…, CM Ensor, FW Holtsberg, JS Bomalaski, MA Clark - Cancer, 2004 - Wiley Online Library
BACKGROUND Argininosuccinate synthetase (ASS) was the first of two enzymes to convert
citrulline to arginine. This pathway allowed cells to synthesize arginine from citrulline, …

Pegylated Arginine Deiminase (ADI-SS PEG20,000 mw) Inhibits Human Melanomas and Hepatocellular Carcinomas in Vitro and in Vivo

…, FW Holtsberg, JS Bomalaski, MA Clark - Cancer …, 2002 - aacrjournals.org
Some murine melanomas and hepatocellular carcinomas (HCCs) have been shown to be
auxotrophic for arginine. Arginine deiminase (ADI; EC 3.5.3.6.), an arginine-degrading …

Antibody humanization: a case of the 'Emperor's new clothes'?

M Clark - Immunology today, 2000 - cell.com
The antiglobulin response is perceived as a major problem in the clinical development of
therapeutic antibodies. Successive technical developments such as chimeric, humanized and, …

Secret key extraction from wireless signal strength in real environments

…, S Jana, J Croft, PL Gowda, M Clark… - IEEE Transactions …, 2012 - ieeexplore.ieee.org
We evaluate the effectiveness of secret key extraction, for private communication between
two wireless devices, from the received signal strength (RSS) variations on the wireless …

Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies

…, FW Holtsberg, JS Bomalaski, MA Clark… - Journal of clinical …, 2004 - ascopubs.org
Purpose Recently, we reported that a large number of human hepatocellular cancer (HCC)
cell lines were auxotrophic for arginine. Here we report the results obtained with the amino …

Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

…, FW Holtsberg, JS Bomalaski, MA Clark… - Journal of Clinical …, 2005 - ascopubs.org
Purpose Individuals with metastatic melanoma have a poor prognosis. Many human melanomas
are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We …

The generation of a humanized, non‐mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

…, H Pope, SD Gorman, M Clark… - European journal of …, 1993 - Wiley Online Library
CD3 antibodies are proven immunosuppressants capable of reversing transplant rejection
episodes. Their general application has been limited both by their immunogenicity and, in …

Mitochondrial transformation of mammalian cells

MA Clark, JW Shay - Nature, 1982 - nature.com
Resistance to the antibiotics chloramphenicol (CAP r ) and efrapeptin (EF r ) in mammalian
cells is cytoplasmically inherited 1,2 . We demonstrate here that purified mitochondria …