The ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly on a
global scale. Although it is clear that severe acute respiratory syndrome coronavirus 2 (SARS-…

Adult neurogenesis, a process of generating functional neurons from adult neural precursors,
occurs throughout life in restricted brain regions in mammals. The past decade has …

Parkinson's disease is the second most common neurodegenerative disorder and is
characterized by the degeneration of dopaminergic neurons in the substantia nigra. Mitochondrial …

Forty years since the initial discovery of neurogenesis in the postnatal rat hippocampus,
investigators have now firmly established that active neurogenesis from neural progenitors …

Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …

Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new
platform to investigate human brain development. High cost, variability, and tissue …

DNA methylation has critical roles in the nervous system and has been traditionally considered
to be restricted to CpG dinucleotides in metazoan genomes. Here we show that the …

Dysregulated neurodevelopment with altered structural and functional connectivity is believed
to underlie many neuropsychiatric disorders 1 , and ‘a disease of synapses’ is the major …

Neurogenesis and gliogenesis continue in discrete regions of the adult mammalian brain. A
fundamental question remains whether cell genesis occurs from distinct lineage-restricted …

The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and
microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing …