Rett syndrome (RTT) is a rare neurodevelopmental disorder characterized by severe
cognitive, social, and physical impairments resulting from de novo mutations in the X-chromosomal …

Most small-molecule drug candidates fail before entering the market, frequently because of
unexpected toxicity. Often, toxicity is detected only late in drug development, because many …

The search continues for a rapid diagnostic test for TB that has high sensitivity and
specificity and is useable in sophisticated environments and in deprived regions with poor …

Motivation: Uridine diphosphate glucunosyltransferases (UGTs) metabolize 15% of FDA
approved drugs. Lead optimization efforts benefit from knowing how candidate drugs are …

Metabolism of drugs affects their absorption, distribution, efficacy, excretion, and toxicity
profiles. Metabolism is routinely assessed experimentally using recombinant enzymes, human …

AIM: To investigate the expression pattern of epithelial cell adhesion molecule (Ep-CAM) on
normal and malignant colon tissues to evaluate its diagnostic and therapeutic significance. …

Cytochromes P450 (CYPs) oxidize alkylated amines commonly found in drugs and other
biologically active molecules, cleaving them into an amine and an aldehyde. Metabolic studies …

Deltas are among the most productive and diverse global ecosystems. However, these regions
are highly vulnerable to natural disasters and climate change. Nature-based solutions (…

Structural alerts are commonly used in drug discovery to identify molecules likely to form
reactive metabolites and thereby become toxic. Unfortunately, as useful as structural alerts are, …

For the first time, we developed a facile, green and low-cost strategy to prepare blue-green
emitting fluorescence copper nanoclusters (Cu NCs) by using tyrosine as a protecting agent …