A semi-synthetic organism with an expanded genetic alphabet
Organisms are defined by the information encoded in their genomes, and since the origin of
life this information has been encoded using a two-base-pair genetic alphabet (A–T and G–…
life this information has been encoded using a two-base-pair genetic alphabet (A–T and G–…
Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA
…, Z Sun, BW Langhorst, L Saleh, S Guan, N Dai… - Genome …, 2021 - genome.cshlp.org
Bisulfite sequencing detects 5mC and 5hmC at single-base resolution. However, bisulfite
treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing …
treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing …
Integration of metal-organic frameworks and covalent organic frameworks: Design, synthesis, and applications
Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), featuring porous
crystalline materials, have attracted tremendous attention for various applications due to …
crystalline materials, have attracted tremendous attention for various applications due to …
Fluorescent DNA-based enzyme sensors
N Dai, ET Kool - Chemical Society Reviews, 2011 - pubs.rsc.org
Fluorescent sensors that make use of DNA structures have become widely useful in monitoring
enzymatic activities. Early studies focused primarily on enzymes that naturally use DNA …
enzymatic activities. Early studies focused primarily on enzymes that naturally use DNA …
Structural basis of RNA cap modification by SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of
COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the …
COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the …
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
A Abakir, TC Giles, A Cristini, JM Foster, N Dai… - Nature …, 2020 - nature.com
R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded
DNA that represent a source of genomic instability in mammalian cells 1 , 2 , 3 – 4 . …
DNA that represent a source of genomic instability in mammalian cells 1 , 2 , 3 – 4 . …
Copper-Catalyzed Radical Relay 1, 3-Carbocarbonylation across Two Distinct C═ C Bonds
NN Dai, YJ Lu, ZQ Wu, Y Zhou, Y Tong, K Tang… - Organic …, 2024 - ACS Publications
The radical relay provides an effective paradigm for intermolecular assembly to achieve
functionalization across remote chemical bonds. Herein, we report the first radical relay 1,3-…
functionalization across remote chemical bonds. Herein, we report the first radical relay 1,3-…
Thermal and mechanical properties of geopolymers exposed to high temperature: a literature review
R He, N Dai, Z Wang - Advances in Civil Engineering, 2020 - Wiley Online Library
Geopolymers are prepared by alkali solution‐activated natural minerals or industrial waste
materials, which have been widely used as new sustainable building and construction …
materials, which have been widely used as new sustainable building and construction …
Dual Nickel/Photoredox-Catalyzed Arylsulfonylation of Allenes
Y Zhou, WH Yang, NN Dai, JY Feng, MQ Yang… - Organic …, 2024 - ACS Publications
The nickel/photoredox dual catalysis system is an efficient conversion platform for the
difunctionalization of unsaturated hydrocarbons. Herein, we disclose the first dual nickel/…
difunctionalization of unsaturated hydrocarbons. Herein, we disclose the first dual nickel/…
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
H Hashimoto, JE Pais, X Zhang, L Saleh, ZQ Fu, N Dai… - Nature, 2014 - nature.com
Cytosine residues in mammalian DNA occur in five forms: cytosine (C), 5-methylcytosine (5mC),
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). …
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). …