Increased nitric oxide (NO) is the main factor leading to the hyperdynamic circulation associated
with advanced portal hypertension (PHT), but the initial mechanisms and the magnitude …

Small organic molecules can assume conformations in the protein-bound state that are
significantly different from those in solution. We have analyzed the conformations of 21 common …

Increased levels of intestinal VEGF are thought to worsen portal hypertension. The cause of
the increase in the level of intestinal VEGF found during cirrhosis is not known. The aim of …

BACKGROUND/AIMS: Cirrhotic livers have a deficient vasodilator response to nitric oxide (NO).
The vasodilator effect of NO is normally limited by the degradation of its second …

HIV protease, an aspartyl protease crucial to the life cycle of HIV, is the target of many drug
development programs. Though many protease inhibitors are on the market, protease …

Clustering of 99 available X-ray crystal structures of HIV-1 reverse transcriptase (RT) at the
flexible non-nucleoside inhibitor binding pocket (NNIBP) provides information about features …

Background The reaction of HIV protease to inhibitor therapy is characterized by the
emergence of complex mutational patterns which confer drug resistance. The response of HIV …

Background and Aim: Livers from lipopolysaccharide‐treated rats have a decreased
vascular response to α 1 ‐adrenergic agonists due to an increased production of nitric oxide. …

Purpose. We examined current osteoporosis prevention practices in patients with inflammatory
bowel disease (IBD) on chronic steroid using the 2003 American Gastroenterological …

Purpose: There is little data on whether multiple positive fecal immunochemical tests (FIT)
correlate with a higher rate of detecting dysplastic lesions on colonoscopy. We compared …