User profiles for A. Shimpi

Adrian A. Shimpi

- Verified email at virginia.edu - Cited by 441

Apurv Prabhakar Shimpi

- Verified email at sha.edu.in - Cited by 255

Efficacy of rapid IV administration of valproic acid for status epilepticus

NA Limdi, AV Shimpi, E Faught, CR Gomez, JG Burneo - Neurology, 2005 - neurology.org
Although not approved by the US Food and Drug Administration for the treatment of status
epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors …

The European genome-phenome archive in 2021

…, M Rueda, A Sankar, D Shaju, A Shimpi… - Nucleic Acids …, 2022 - academic.oup.com
The European Genome-phenome Archive (EGA - https://ega-archive.org/ ) is a resource for
long term secure archiving of all types of potentially identifiable genetic, phenotypic, and …

Measuring and modelling tumour heterogeneity across scales

GF Beeghly, AA Shimpi, RN Riter… - Nature Reviews …, 2023 - nature.com
Cancer development, progression and therapy response are heterogeneous and patient-specific.
The biological and physical properties of tumour cells and their surrounding tissue …

Collagen microarchitecture mechanically controls myofibroblast differentiation

BR Seo, X Chen, L Ling, YH Song, AA Shimpi… - Proceedings of the …, 2020 - pnas.org
Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …

Engineered ECM models: Opportunities to advance understanding of tumor heterogeneity

AA Shimpi, C Fischbach - Current opinion in cell biology, 2021 - Elsevier
Intratumoral heterogeneity is a negative prognostic factor for cancer and commonly attributed
to microenvironment-driven genetic mutations and/or the emergence of cancer stem-like …

Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer

S Choi, MA Whitman, AA Shimpi… - Nature Biomedical …, 2023 - nature.com
In patients with breast cancer, lower bone mineral density increases the risk of bone
metastasis. Although the relationship between bone-matrix mineralization and tumour-cell …

[HTML][HTML] The learning curve for magnetic resonance imaging/ultrasound fusion-guided prostate biopsy

…, N Patel, E Cricco-Lizza, AA Shimpi… - European Urology …, 2019 - Elsevier
Background Magnetic resonance imaging/ultrasound-guided fusion biopsy (FBx) is more
accurate at detecting clinically significant prostate cancer than conventional transrectal …

An empirical explanation of the Cornsweet effect

D Purves, A Shimpi, RB Lotto - Journal of Neuroscience, 1999 - jneurosci.org
A long-standing puzzle in vision is the assignment of illusory brightness values to visual
territories based on the characteristics of their edges (the Craik–O’Brien–Cornsweet effect). …

Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling

…, JA Mulligan, Y Ouyang, AA Shimpi… - Advanced functional …, 2020 - Wiley Online Library
Obesity increases the risk and worsens the prognosis for breast cancer due, in part, to
altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase …

Suryanamaskar: An equivalent approach towards management of physical fitness in obese females

KA Jakhotia, AP Shimpi, SA Rairikar… - … Journal of Yoga, 2015 - journals.lww.com
Background: In India, obesity is highly prevalent in women as compared to men. As the obesity
epidemic spreads, there are growing concerns about efficient obesity management. Aims…