The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment
Objective Coronavirus disease 2019 (COVID-19) poses societal challenges that require
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African
ancestry compared to women of European ancestry. In search of common risk alleles for …
ancestry compared to women of European ancestry. In search of common risk alleles for …
DPYD Variants as Predictors of 5-fluorouracil Toxicity in Adjuvant Colon Cancer Treatment (NCCTG N0147)
AM Lee, Q Shi, E Pavey, SR Alberts… - Journal of the …, 2014 - academic.oup.com
Background Previous studies have suggested the potential importance of three DPYD variants
(DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, …
(DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, …
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor
status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative …
status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative …
Association of choroid plexus enlargement with cognitive, inflammatory, and structural phenotypes across the psychosis spectrum
Objective: The choroid plexus is an important physiological barrier and produces CSF and
neurotrophic, angiogenic, and inflammatory factors involved in brain development. Choroid …
neurotrophic, angiogenic, and inflammatory factors involved in brain development. Choroid …
Common breast cancer susceptibility loci are associated with triple-negative breast cancer
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival,
but there remains little known about the etiologic factors that promote its initiation and …
but there remains little known about the etiologic factors that promote its initiation and …
Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis
Elevations in peripheral inflammatory markers have been reported in patients with psychosis.
Whether this represents an inflammatory process defined by individual or subgroups of …
Whether this represents an inflammatory process defined by individual or subgroups of …
Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes
Sex differences have been widely observed in human health. However, little is known about
the underlying mechanism behind these observed sex differences. We hypothesize that sex-…
the underlying mechanism behind these observed sex differences. We hypothesize that sex-…
Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder
Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …
A DPYD Variant (Y186C) in Individuals of African Ancestry Is Associated With Reduced DPD Enzyme Activity
SM Offer, AM Lee, LK Mattison… - Clinical …, 2013 - Wiley Online Library
5‐Fluorouracil (5‐FU) is used to treat many aggressive cancers, such as those of the colon,
breast, and head and neck. The responses to 5‐FU, with respect to both toxicity and efficacy, …
breast, and head and neck. The responses to 5‐FU, with respect to both toxicity and efficacy, …