Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …

In cancer treatment, apoptosis is a well-recognized cell death mechanism through which
cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic process …

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource
that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). …

Whole genome RNA expression studies permit systematic approaches to understanding the
correlation between gene expression profiles to disease states or different developmental …

Purpose: To define the genetic landscape of advanced differentiated and anaplastic thyroid
cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and …

Most of the studies characterizing DNA methylation patterns have been restricted to particular
genomic loci in a limited number of human samples and pathological conditions. Herein, …

Motivation: Various studies have shown that cancer tissue samples can be successfully
detected and classified by their gene expression patterns using machine learning approaches. …

The prognosis of breast cancer in young women is influenced by reproductive history. Women
diagnosed within 5 years postpartum have worse prognosis than nulliparous women or …

Purpose: Anaplastic lymphoma kinase (ALK) rearrangements, associated with sensitivity to
an experimental ALK/MET inhibitor, occur in 3% to 5% of non–small cell lung cancers. …

The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or
tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown …