Background Treatment with peginterferon alfa-2a alone produces significantly higher sustained
virologic responses than treatment with interferon alfa-2a alone in patients with chronic …

Background: Treatment with pegylated interferon (peginterferon) and ribavirin for 48 weeks
is more effective than conventional interferon and ribavirin in patients with chronic hepatitis C…

Background Covalent attachment of a 40-kd branched-chain polyethylene glycol moiety to
interferon alfa-2a results in a compound (peginterferon alfa-2a) that has sustained absorption, …

Background Chronic hepatitis C virus (HCV) infection in patients with cirrhosis is difficult to
treat. In patients with chronic hepatitis C but without cirrhosis, once-weekly administration of …

… These practices, in which bilinguals “intermingle linguistic features that have hereto been
administratively or linguistically assigned to a particular language or language variety” (p. 51), …

Background Patients infected with hepatitis C virus (HCV) genotype 2 or 3 have sustained
virologic response rates of approximately 80% after receiving treatment with peginterferon …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Hallmark deregulated signaling in cancer cells drives excessive ribosome biogenesis within
the nucleolus, which elicits unbridled cell growth and proliferation. The rate-limiting step of …

Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation.
RNA polymerase (Pol) I, the multiprotein complex that synthesizes rRNA, is activated …

Abnormal accumulation of β-amyloid (Aβ) in Alzheimer's disease (AD) is associated with
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …