Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)
kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-…

Saliency is an important perceptual cue that occurs at different levels of resolution. Important
attributes of saliency are symmetry, continuity, and closure. Detection of these attributes is …

A wealth of evidence has now demonstrated that the microenvironment in which a tumorigenic
cell evolves is as critical to its evolution as the genetic mutations it accrues. However, …

Although high mammographic density is considered one of the strongest risk factors for
invasive breast cancer, the genes involved in modulating this clinical feature are unknown. …

… Bahram Parvin; Bahram Parvin … Costes, Arnaud Boissière, Shraddha Ravani, Raquel
Romano, Bahram Parvin, Mary Helen Barcellos-Hoff; Imaging Features that Discriminate between …

Histology is the microscopic inspection of plant or animal tissue. It is a critical component in
diagnostic medicine and a tool for studying the pathogenesis and biology of processes such …

Image-based classification of histology sections plays an important role in predicting clinical
outcomes. However this task is very challenging due to the presence of large technical …

Protein isoforms produced by alternative splicing (AS) of many genes have been implicated
in several aspects of cancer genesis and progression. These observations motivated a …

Automated analysis of whole mount tissue sections can provide insights into tumor subtypes
and the underlying molecular basis of neoplasm. However, since tumor sections are …

Practical data mining rarely falls exactly into the supervised learning scenario. Rather, the
growing amount of unlabeled data poses a big challenge to large-scale semi-supervised …