Targeting ferroptosis as a novel approach to alleviate aortic dissection
N Li, X Yi, Y He, B Huo, Y Chen… - … journal of biological …, 2022 - pmc.ncbi.nlm.nih.gov
A variety of programmed cell death types have been shown to participate in the loss of smooth
muscle cells (SMCs) during the development of aortic dissection (AD), but it is still largely …
muscle cells (SMCs) during the development of aortic dissection (AD), but it is still largely …
[HTML][HTML] BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection
Y Chen, X Yi, B Huo, Y He, X Guo, Z Zhang… - Pharmacological …, 2022 - Elsevier
Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic
dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the …
dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the …
Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation
by activating biochemical pathways and mediating the cellular activities of other bone cells. …
by activating biochemical pathways and mediating the cellular activities of other bone cells. …
Calcium response in osteocytic networks under steady and oscillatory fluid flow
The fluid flow in the lacunar–canalicular system of bone is an essential mechanical stimulation
on the osteocyte networks. Due to the complexity of human physical activities, the fluid …
on the osteocyte networks. Due to the complexity of human physical activities, the fluid …
Competitive binding to cuprous ions of protein and BCA in the bicinchoninic acid protein assay
T Huang, M Long, B Huo - The open biomedical engineering …, 2010 - pmc.ncbi.nlm.nih.gov
Although Bicinchoninic acid (BCA) has been widely used to determine protein concentration,
the mechanism of interaction between protein, copper ion and BCA in this assay is still not …
the mechanism of interaction between protein, copper ion and BCA in this assay is still not …
Nickel-catalyzed cross-electrophile coupling of aryl thiols with aryl bromides via C–S bond activation
H Xu, CY He, BJ Huo, JW Jing, C Miao… - Organic Chemistry …, 2023 - pubs.rsc.org
The reaction of aryl thiols with aryl bromides usually provides thioethers as the major products,
even in the presence of a transition metal catalyst and a zinc mediator. We report here a …
even in the presence of a transition metal catalyst and a zinc mediator. We report here a …
[HTML][HTML] SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells
Y He, X Wang, S Chen, H Luo, B Huo, X Guo… - Free Radical Biology …, 2024 - Elsevier
Previous studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is
involved in the development of aortic dissection (AD) and that histone methylation regulates …
involved in the development of aortic dissection (AD) and that histone methylation regulates …
Stiff substrates enhance cultured neuronal network activity
…, J Xie, CX Li, WY Chen, BL Liu, X Wu, SN Li, B Huo… - Scientific reports, 2014 - nature.com
The mechanical property of extracellular matrix and cell-supporting substrates is known to
modulate neuronal growth, differentiation, extension and branching. Here we show that …
modulate neuronal growth, differentiation, extension and branching. Here we show that …
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis
J Shi, QH Wang, X Wei, B Huo, JN Ye, X Yi, X Feng… - Molecular …, 2023 - Springer
Background E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase,
contributes to modifications of the chromatin landscape of genes involved in multiple …
contributes to modifications of the chromatin landscape of genes involved in multiple …
EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection
R Li, X Yi, X Wei, B Huo, X Guo, C Cheng… - Cell death & …, 2018 - nature.com
Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27
of histone H3, largely functions as a transcriptional repressor, and plays a critical role in …
of histone H3, largely functions as a transcriptional repressor, and plays a critical role in …