SNAP-25 is a component of the SNARE complex implicated in synaptic vesicle exocytosis.
In this study, we demonstrate that hippocampal GABAergic synapses, both in culture and in …

Action potential (AP) generation in inhibitory interneurons is critical for cortical excitation-inhibition
balance and information processing. However, it remains unclear what determines AP …

Dynamic modulation of the actin cytoskeleton is critical for synaptic plasticity, abnormalities
of which are thought to contribute to mental illness and addiction. Here we report that mice …

Background information ATP is the main transmitter stored and released from astrocytes
under physiological and pathological conditions. Morphological and functional evidence …

During development of neuronal circuits, presynaptic and postsynaptic functions are adjusted
in concert, to optimize interneuronal signaling. We have investigated whether activation of …

Synaptosomal-associated protein of 25 kDa (SNAP-25) is a protein that participates in the
regulation of synaptic vesicle exocytosis through the formation of the soluble NSF attachment …

Objective Hippocampal sclerosis ( HS ) is the major structural brain lesion in patients with
temporal lobe epilepsy ( TLE ). However, its internal anatomic structure remains difficult to …

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter
release through their cleavage of components of the exocytosis machinery. These …

SCN1A (Na V 1.1 sodium channel) mutations cause Dravet syndrome (DS) and GEFS+ (which
is in general milder), and are risk factors in other epilepsies. Phenotypic variability limits …

The relationships between impaired cortical development and consequent malformations in
neurodevelopmental disorders, as well as the genes implicated in these processes, are not …