N 6 -methyladenosine (m 6 A) is the most prevalent internal (non-cap) modification present
in the messenger RNA of all higher eukaryotes 1 , 2 . Although essential to cell viability and …

Over 100 types of chemical modifications have been identified in cellular RNAs. While the 5′
cap modification and the poly(A) tail of eukaryotic mRNA play key roles in regulation, …

5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic
imprinting, and suppression of transposable elements. 5mC can be converted to 5-…

N 6 -methyladenosine (m 6 A) regulates stability and translation of messenger RNA (mRNA)
in various biological processes. In this work, we show that knockout of the m 6 A writer …

We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N6-methyladenosine (m 6 A) residues in RNA in …

There is growing evidence that tumour neoantigens have important roles in generating
spontaneous antitumour immune responses and predicting clinical responses to …

N 6 -methyladenosine (m 6 A) is the most prevalent and reversible internal modification in
mammalian messenger and noncoding RNAs. We report here that human methyltransferase-…

N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …

RNA carries a diverse array of chemical modifications that play important roles in the regulation
of gene expression. N 6 ‐methyladenosine (m 6 A), installed onto mRNA by the METTL3/…

The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine
(5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the Tet (…